{"id":15567,"date":"2022-12-01T08:40:02","date_gmt":"2022-12-01T08:40:02","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=15567"},"modified":"2022-12-01T08:40:02","modified_gmt":"2022-12-01T08:40:02","slug":"diet-drugs-novel-approach-mosquito-control","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/cs\/science\/life-sciences\/diet-drugs-novel-approach-mosquito-control\/","title":{"rendered":"Boj s kom\u00e1ry nov\u011b: Dietetick\u00e9 l\u00e9ky proti krve\u017e\u00edzniv\u00fdm \u0161k\u016fdc\u016fm"},"content":{"rendered":"

Dietetick\u00e9 l\u00e9ky: Nov\u00fd p\u0159\u00edstup k regulaci kom\u00e1r\u016f<\/h2>\n\n

Kom\u00e1\u0159i: Obt\u00ed\u017e zp\u016fsoben\u00e1 hladem<\/h2>\n\n

Na kom\u00e1ry se \u010dasto pohl\u00ed\u017e\u00ed pouze jako na \u0161k\u016fdce, kte\u0159\u00ed n\u00e1m znep\u0159\u00edjem\u0148uj\u00ed pobyt venku. Jejich krvesaj\u00edc\u00ed chov\u00e1n\u00ed je v\u0161ak zp\u016fsobeno biologickou pot\u0159ebou: sami\u010d\u00ed kom\u00e1\u0159i pot\u0159ebuj\u00ed kladnout vaj\u00ed\u010dka krev. Tento hlad je nut\u00ed vyhled\u00e1vat jako zdroj potravy \u010dlov\u011bka a zv\u00ed\u0159ata.<\/p>\n\n

Dietetick\u00e9 l\u00e9ky a potla\u010den\u00ed chuti k j\u00eddlu u kom\u00e1r\u016f<\/h2>\n\n

V\u011bdci objevili nov\u00fd p\u0159\u00edstup k regulaci kom\u00e1r\u016f: vyu\u017eit\u00ed dietetick\u00fdch l\u00e9k\u016f k potla\u010den\u00ed jejich chuti k j\u00eddlu. Tyto l\u00e9ky, kter\u00e9 c\u00edl\u00ed na receptory neuropeptidu Y (NPY), jsou zn\u00e1my t\u00edm, \u017ee reguluj\u00ed chu\u0165 k j\u00eddlu u lid\u00ed a jin\u00fdch zv\u00ed\u0159at.<\/p>\n\n

Zam\u011b\u0159en\u00ed na NPYLR7: Kl\u00ed\u010d k potla\u010den\u00ed chuti k j\u00eddlu<\/h2>\n\n

Jeden specifick\u00fd NPY receptor, NPYLR7, identifikovali v\u011bdci jako kl\u00ed\u010d k potla\u010den\u00ed chuti k j\u00eddlu u kom\u00e1r\u016f. Pomoc\u00ed technik editace gen\u016f vytvo\u0159ili v\u011bdci kom\u00e1ry, kte\u0159\u00ed nedok\u00e1\u017eou produkovat NPYLR7. Tito kom\u00e1\u0159i nejsou ovlivn\u011bni dietetick\u00fdmi l\u00e9ky, co\u017e d\u00e1le potvrzuje roli NPYLR7 p\u0159i regulaci hladu.<\/p>\n\n

Slou\u010denina 18: Slibn\u00e1 alternativa k dietetick\u00fdm l\u00e9k\u016fm pro lidi<\/h2>\n\n

Pou\u017eit\u00ed dietetick\u00fdch l\u00e9k\u016f pro lidi k regulaci kom\u00e1r\u016f je nepraktick\u00e9 z d\u016fvodu bezpe\u010dnostn\u00edch probl\u00e9m\u016f a ot\u00e1zek patent\u016f. Proto v\u011bdci prov\u011b\u0159ili v\u00edce ne\u017e 265 000 slou\u010denin, aby na\u0161li takovou, kter\u00e1 by aktivovala receptor NPYLR7. Slou\u010denina 18 se uk\u00e1zala b\u00fdt slibn\u00fdm kandid\u00e1tem a po expozici \u00fa\u010dinn\u011b inhibovala kousac\u00ed chov\u00e1n\u00ed kom\u00e1r\u016f.<\/p>\n\n

V\u00fdhody metody dietetick\u00fdch l\u00e9k\u016f pro regulaci kom\u00e1r\u016f<\/h2>\n\n

Metoda dietetick\u00fdch l\u00e9k\u016f nab\u00edz\u00ed n\u011bkolik v\u00fdhod oproti jin\u00fdm technik\u00e1m regulace kom\u00e1r\u016f. Na rozd\u00edl od vypou\u0161t\u011bn\u00ed sterilizovan\u00fdch samc\u016f nebo geneticky modifikovan\u00fdch kom\u00e1r\u016f, co\u017e m\u016f\u017ee m\u00edt nep\u0159\u00edzniv\u00e9 dopady na \u017eivotn\u00ed prost\u0159ed\u00ed, metoda dietetick\u00fdch l\u00e9k\u016f si klade za c\u00edl omezit populace kom\u00e1r\u016f, ani\u017e by je vyhubila. Tento p\u0159\u00edstup zachov\u00e1v\u00e1 m\u00edstn\u00ed ekosyst\u00e9my a zabra\u0148uje ne\u00famysln\u00e9mu po\u0161kozov\u00e1n\u00ed jin\u00fdch druh\u016f.<\/p>\n\n

Omezen\u00ed a budouc\u00ed vyhl\u00eddky<\/h2>\n\n

P\u0159esto\u017ee se metoda dietetick\u00fdch l\u00e9k\u016f uk\u00e1zala jako slibn\u00e1, je d\u016fle\u017eit\u00e9 si uv\u011bdomit jej\u00ed omezen\u00ed. \u017d\u00e1dn\u00fd jednotn\u00fd p\u0159\u00edstup k regulaci kom\u00e1r\u016f nen\u00ed bezchybn\u00fd a metoda dietetick\u00fdch l\u00e9k\u016f nen\u00ed v\u00fdjimkou. V\u011bdci uva\u017euj\u00ed o jej\u00edm pou\u017eit\u00ed spole\u010dn\u011b s jin\u00fdmi strategiemi, jako jsou insekticidy nebo GMO kom\u00e1\u0159i, aby dos\u00e1hli optim\u00e1ln\u00edch v\u00fdsledk\u016f.<\/p>\n\n

Slou\u010denina 18: Potenci\u00e1ln\u00ed n\u00e1stroj pro integrovanou regulaci kom\u00e1r\u016f<\/h2>\n\n

Slou\u010denina 18, nejslibn\u011bj\u0161\u00ed kandid\u00e1t identifikovan\u00fd ve studii, by se mohla st\u00e1t cenn\u00fdm n\u00e1strojem integrovan\u00e9 regulace kom\u00e1r\u016f. Naru\u0161en\u00edm potravn\u00edho chov\u00e1n\u00ed kom\u00e1r\u016f m\u00e1 potenci\u00e1l sn\u00ed\u017eit p\u0159enos nemoc\u00ed, zlep\u0161it ve\u0159ejn\u00e9 zdrav\u00ed a zv\u00fd\u0161it na\u0161e pot\u011b\u0161en\u00ed z pobytu venku.<\/p>\n\n

Prob\u00edhaj\u00edc\u00ed v\u00fdzkum a budouc\u00ed aplikace<\/h2>\n\n

Aby bylo mo\u017en\u00e9 ur\u010dit bezpe\u010dnost a \u00fa\u010dinnost slou\u010deniny 18 v ter\u00e9nn\u00edch podm\u00ednk\u00e1ch, je zapot\u0159eb\u00ed dal\u0161\u00ed v\u00fdzkum. V\u011bdci tak\u00e9 zkoumaj\u00ed mo\u017enost pou\u017eit\u00ed stejn\u00e9 chemick\u00e9 l\u00e1tky k regulaci jin\u00e9ho hmyzu, kter\u00fd se \u017eiv\u00ed lidmi, jako jsou kl\u00ed\u0161\u0165ata. Neust\u00e1l\u00fdm inovov\u00e1n\u00edm a zdokonalov\u00e1n\u00edm tohoto p\u0159\u00edstupu m\u016f\u017eeme vyvinout \u00fa\u010dinn\u011bj\u0161\u00ed a ekologi\u010dt\u011bj\u0161\u00ed strategie regulace kom\u00e1r\u016f.<\/p>\n\n

Z\u00e1v\u011br<\/h2>\n\n

Metoda dietetick\u00fdch l\u00e9k\u016f p\u0159edstavuje slibn\u00fd nov\u00fd p\u0159\u00edstup k regulaci kom\u00e1r\u016f. Zam\u011b\u0159en\u00edm na receptor NPYLR7 slou\u010denina 18 \u00fa\u010dinn\u011b potla\u010duje hlad a kousac\u00ed chov\u00e1n\u00ed kom\u00e1r\u016f. P\u0159esto\u017ee je p\u0159ed \u0161irok\u00fdm zaveden\u00edm t\u00e9to metody zapot\u0159eb\u00ed dal\u0161\u00ed v\u00fdzkum, m\u00e1 potenci\u00e1l st\u00e1t se d\u016fle\u017eit\u00fdm n\u00e1strojem v boji proti nemocem p\u0159en\u00e1\u0161en\u00fdm kom\u00e1ry a zlep\u0161it ve\u0159ejn\u00e9 zdrav\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>","protected":false},"excerpt":{"rendered":"

Dietetick\u00e9 l\u00e9ky: Nov\u00fd p\u0159\u00edstup k regulaci kom\u00e1r\u016f Kom\u00e1\u0159i: Obt\u00ed\u017e zp\u016fsoben\u00e1 hladem Na kom\u00e1ry se \u010dasto pohl\u00ed\u017e\u00ed pouze jako na \u0161k\u016fdce, kte\u0159\u00ed n\u00e1m znep\u0159\u00edjem\u0148uj\u00ed pobyt venku. Jejich krvesaj\u00edc\u00ed chov\u00e1n\u00ed je v\u0161ak…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762],"tags":[20732,20734,233,20731,20733],"class_list":["post-15567","post","type-post","status-publish","format-standard","hentry","category-life-sciences","tag-appetite-suppression","tag-compound-18","tag-mosquito-control","tag-diet-drugs","tag-npy-receptor"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/15567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/comments?post=15567"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/15567\/revisions"}],"predecessor-version":[{"id":15568,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/15567\/revisions\/15568"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/media?parent=15567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/categories?post=15567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/tags?post=15567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}