{"id":17155,"date":"2019-04-08T11:29:51","date_gmt":"2019-04-08T11:29:51","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=17155"},"modified":"2019-04-08T11:29:51","modified_gmt":"2019-04-08T11:29:51","slug":"neurogenesis-new-findings-and-implications-for-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/cs\/science\/neuroscience\/neurogenesis-new-findings-and-implications-for-alzheimers-disease\/","title":{"rendered":"Neurogeneze: Nov\u00e9 poznatky a d\u016fsledky pro Alzheimerovu chorobu"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Neurogeneze: Nov\u00e9 poznatky a d\u016fsledky pro Alzheimerovu chorobu<\/h2>\n\n<h2 class=\"wp-block-heading\">Co je neurogeneze?<\/h2>\n\n<p>Neurogeneze je proces, kter\u00fdm vznikaj\u00ed v mozku nov\u00e9 neurony. D\u0159\u00edve se v\u011b\u0159ilo, \u017ee tento proces prob\u00edh\u00e1 pouze v d\u011btstv\u00ed, ale ned\u00e1vn\u00e9 v\u00fdzkumy uk\u00e1zaly, \u017ee neurogeneze pokra\u010duje i v dosp\u011blosti, dokonce i ve st\u00e1\u0159\u00ed.<\/p>\n\n<h2 class=\"wp-block-heading\">Neurogeneze a Alzheimerova choroba<\/h2>\n\n<p>Alzheimerova choroba je neurodegenerativn\u00ed onemocn\u011bn\u00ed, kter\u00e9 se vyzna\u010duje ztr\u00e1tou neuron\u016f v mozku. Tato ztr\u00e1ta neuron\u016f vede ke zhor\u0161en\u00ed kognitivn\u00edch funkc\u00ed, pam\u011bti a chov\u00e1n\u00ed.<\/p>\n\n<p>V\u00fdzkumy uk\u00e1zaly, \u017ee u lid\u00ed s Alzheimerovou chorobou je neurogeneze naru\u0161ena. Toto naru\u0161en\u00ed m\u016f\u017ee p\u0159isp\u00edvat ke kognitivn\u00edmu poklesu, kter\u00fd je charakteristick\u00fd pro toto onemocn\u011bn\u00ed.<\/p>\n\n<h2 class=\"wp-block-heading\">Nov\u00e9 poznatky o neurogenezi<\/h2>\n\n<p>Ned\u00e1vn\u00e1 studie publikovan\u00e1 v \u010dasopise Nature Medicine zjistila, \u017ee neurogeneze pokra\u010duje i ve st\u00e1\u0159\u00ed, dokonce i v 90. letech. Tato studie analyzovala 58 vzork\u016f mozku od lid\u00ed ve v\u011bku od 43 do 97 let a zjistila, \u017ee neurogeneze s p\u0159ib\u00fdvaj\u00edc\u00edm v\u011bkem kles\u00e1. Nicm\u00e9n\u011b i nejstar\u0161\u00ed d\u00e1rci m\u011bli n\u011bjak\u00e9 nov\u011b vytvo\u0159en\u00e9 neurony.<\/p>\n\n<p>Studie tak\u00e9 zjistila, \u017ee u lid\u00ed s Alzheimerovou chorobou byla neurogeneze naru\u0161ena. Toto naru\u0161en\u00ed bylo obzvl\u00e1\u0161t\u011b v\u00fdrazn\u00e9 u lid\u00ed, kter\u00fdm byla tato choroba diagnostikov\u00e1na p\u0159ed jejich \u00famrt\u00edm.<\/p>\n\n<h2 class=\"wp-block-heading\">D\u016fsledky pro l\u00e9\u010dbu Alzheimerovy choroby<\/h2>\n\n<p>Zji\u0161t\u011bn\u00ed t\u00e9to studie maj\u00ed d\u016fle\u017eit\u00e9 d\u016fsledky pro l\u00e9\u010dbu Alzheimerovy choroby. Pokud neurov\u011bdci najdou zp\u016fsob, jak detekovat nov\u011b vytvo\u0159en\u00e9 neurony u \u017eij\u00edc\u00edch lid\u00ed, mohou b\u00fdt schopni diagnostikovat toto onemocn\u011bn\u00ed v jeho nejran\u011bj\u0161\u00edch st\u00e1di\u00edch. Tato v\u010dasn\u00e1 diagn\u00f3za by mohla v\u00e9st k d\u0159\u00edv\u011bj\u0161\u00ed l\u00e9\u010db\u011b, kter\u00e1 by mohla zpomalit nebo zabr\u00e1nit progresi onemocn\u011bn\u00ed.<\/p>\n\n<h2 class=\"wp-block-heading\">V\u00fdzvy a budouc\u00ed sm\u011bry<\/h2>\n\n<p>Jednou z v\u00fdzev p\u0159i studiu neurogeneze je obt\u00ed\u017enost detekce nov\u011b vytvo\u0159en\u00fdch neuron\u016f v mozkov\u00e9 tk\u00e1ni. V\u00fdzkumn\u00edci pracuj\u00ed na v\u00fdvoji nov\u00fdch metod, jak tuto v\u00fdzvu p\u0159ekonat.<\/p>\n\n<p>Dal\u0161\u00ed v\u00fdzvou je pot\u0159eba naj\u00edt zp\u016fsoby, jak podpo\u0159it neurogenezi u lid\u00ed s Alzheimerovou chorobou. V\u00fdzkumn\u00edci zkoumaj\u00ed r\u016fzn\u00e9 p\u0159\u00edstupy k tomuto probl\u00e9mu, v\u010detn\u011b l\u00e9k\u016f, cvi\u010den\u00ed a dietn\u00edch intervenc\u00ed.<\/p>\n\n<h2 class=\"wp-block-heading\">Z\u00e1v\u011br<\/h2>\n\n<p>V\u00fdzkum neurogeneze je st\u00e1le v ran\u00fdch st\u00e1di\u00edch, ale dosavadn\u00ed zji\u0161t\u011bn\u00ed maj\u00ed d\u016fle\u017eit\u00e9 d\u016fsledky pro l\u00e9\u010dbu Alzheimerovy choroby. Pochopen\u00edm role neurogeneze p\u0159i tomto onemocn\u011bn\u00ed mohou b\u00fdt v\u011bdci schopni vyvinout nov\u00e9 terapie, kter\u00e9 zabr\u00e1n\u00ed jeho rozvoji nebo jej zpomal\u00ed.<\/p>\n\n<h2 class=\"wp-block-heading\">Dal\u0161\u00ed informace<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00e9 jsou v\u00fdhody neurogeneze pro lidi s depres\u00ed?<\/strong><\/li>\n<\/ul>\n\n<p>Bylo prok\u00e1z\u00e1no, \u017ee neurogeneze m\u00e1 \u0159adu v\u00fdhod pro lidi s depres\u00ed, v\u010detn\u011b zlep\u0161en\u00ed n\u00e1lady, sn\u00ed\u017een\u00ed \u00fazkosti a zv\u00fd\u0161en\u00ed kognitivn\u00edch funkc\u00ed.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00e9 jsou d\u016fsledky pokra\u010duj\u00edc\u00ed neurogeneze pro posttraumatickou stresovou poruchu?<\/strong><\/li>\n<\/ul>\n\n<p>Pokra\u010duj\u00edc\u00ed neurogeneze m\u016f\u017ee pomoci lidem s posttraumatickou stresovou poruchou (PTSD) zotavit se z jejich p\u0159\u00edznak\u016f. Bylo prok\u00e1z\u00e1no, \u017ee neurogeneze podporuje vytv\u00e1\u0159en\u00ed nov\u00fdch vzpom\u00ednek, co\u017e m\u016f\u017ee lidem pomoci zpracovat a p\u0159ekonat traumatick\u00e9 z\u00e1\u017eitky.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Je mo\u017en\u00e9 detekovat nov\u011b vytvo\u0159en\u00e9 neurony u \u017eij\u00edc\u00edch lid\u00ed?<\/strong><\/li>\n<\/ul>\n\n<p>V\u00fdzkumn\u00edci pracuj\u00ed na v\u00fdvoji nov\u00fdch metod pro detekci nov\u011b vytvo\u0159en\u00fdch neuron\u016f u \u017eij\u00edc\u00edch lid\u00ed. Je to n\u00e1ro\u010dn\u00fd \u00fakol, ale je nezbytn\u00fd pro v\u00fdvoj nov\u00fdch l\u00e9\u010debn\u00fdch postup\u016f pro Alzheimerovu chorobu a dal\u0161\u00ed neurodegenerativn\u00ed poruchy.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00fd dopad by mohla m\u00edt v\u010dasn\u00e1 detekce Alzheimerovy choroby na l\u00e9\u010dbu?<\/strong><\/li>\n<\/ul>\n\n<p>V\u010dasn\u00e1 detekce Alzheimerovy choroby by mohla v\u00e9st k d\u0159\u00edv\u011bj\u0161\u00ed l\u00e9\u010db\u011b, kter\u00e1 by mohla zpomalit nebo zabr\u00e1nit progresi onemocn\u011bn\u00ed. To by mohlo m\u00edt v\u00fdznamn\u00fd vliv na kvalitu \u017eivota lid\u00ed s Alzheimerovou chorobou a jejich rodin.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00e1 jsou potenci\u00e1ln\u00ed rizika a p\u0159\u00ednosy pou\u017eit\u00ed paraformaldehydu ke konzervaci mozkov\u00e9 tk\u00e1n\u011b pro v\u00fdzkum?<\/strong><\/li>\n<\/ul>\n\n<p>Paraformaldehyd je chemick\u00e1 l\u00e1tka, kter\u00e1 se pou\u017e\u00edv\u00e1 ke konzervaci mozkov\u00e9 tk\u00e1n\u011b pro v\u00fdzkum. Je to dobr\u00fd konzervant, ale m\u016f\u017ee tak\u00e9 znesnadnit detekci nov\u011b vytvo\u0159en\u00fdch neuron\u016f. V\u00fdzkumn\u00edci pracuj\u00ed na v\u00fdvoji nov\u00fdch metod pro konzervaci mozkov\u00e9 tk\u00e1n\u011b, kter\u00e9 nemaj\u00ed tento probl\u00e9m.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak mohou neurov\u011bdci p\u0159ekonat v\u00fdzvy spojen\u00e9 s detekc\u00ed nezral\u00fdch neuron\u016f v mozkov\u00e9 tk\u00e1ni?<\/strong><\/li>\n<\/ul>\n\n<p>Neurov\u011bdci pracuj\u00ed na v\u00fdvoji nov\u00fdch metod pro detekci nezral\u00fdch neuron\u016f v mozkov\u00e9 tk\u00e1ni. Tyto metody zahrnuj\u00ed pou\u017eit\u00ed protil\u00e1tek specifick\u00fdch pro nezral\u00e9 neurony a pou\u017eit\u00ed zobrazovac\u00edch technik, kter\u00e9 dok\u00e1\u017e\u00ed nezral\u00e9 neurony vizualizovat.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00fd je v\u00fdznam nov\u00fdch poznatk\u016f madridsk\u00e9ho t\u00fdmu o neurogenezi?<\/strong><\/li>\n<\/ul>\n\n<p>Nov\u00e9 poznatky madridsk\u00e9ho t\u00fdmu o neurogenezi jsou v\u00fdznamn\u00e9, proto\u017ee poskytuj\u00ed siln\u00e9 d\u016fkazy o tom, \u017ee neurogeneze pokra\u010duje i ve st\u00e1\u0159\u00ed. Toto zji\u0161t\u011bn\u00ed m\u00e1 d\u016fle\u017eit\u00e9 d\u016fsledky pro l\u00e9\u010dbu Alzheimerovy choroby a dal\u0161\u00edch neurodegenerativn\u00edch poruch.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jak\u00e9 jsou etick\u00e9 implikace pou\u017eit\u00ed mozkov\u00e9 tk\u00e1n\u011b zem\u0159el\u00fdch osob pro v\u00fdzkum?<\/strong><\/li>\n<\/ul>\n\n<p>Pou\u017eit\u00ed mozkov\u00e9 tk\u00e1n\u011b zem\u0159el\u00fdch osob pro v\u00fdzkum vyvol\u00e1v\u00e1 \u0159adu etick\u00fdch ot\u00e1zek, v\u010detn\u011b ot\u00e1zky souhlasu. V\u00fdzkumn\u00edci mus\u00ed z\u00edskat informovan\u00fd souhlas od osob, kter\u00e9 daruj\u00ed svou mozkovou tk\u00e1\u0148 pro v\u00fdzkum.<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Jakou roli hraje protein doublecortin (DCX) p\u0159i v\u00fdvoji neuron\u016f?<\/strong><\/li>\n<\/ul>\n\n<p>Protein doublecortin (DCX) je protein exprimovan\u00fd v nezral\u00fdch neuronech. Pod\u00edl\u00ed se na migraci a diferenciaci neuron\u016f.<\/p>","protected":false},"excerpt":{"rendered":"<p>Neurogeneze: Nov\u00e9 poznatky a d\u016fsledky pro Alzheimerovu chorobu Co je neurogeneze? Neurogeneze je proces, kter\u00fdm vznikaj\u00ed v mozku nov\u00e9 neurony. D\u0159\u00edve se v\u011b\u0159ilo, \u017ee tento proces prob\u00edh\u00e1 pouze v d\u011btstv\u00ed,&hellip;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[411],"tags":[20997,22642,1579,2303],"class_list":["post-17155","post","type-post","status-publish","format-standard","hentry","category-neuroscience","tag-alzheimers-disease","tag-neurogenesis","tag-neuroscience","tag-brain-health"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/17155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/comments?post=17155"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/17155\/revisions"}],"predecessor-version":[{"id":17156,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/17155\/revisions\/17156"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/media?parent=17155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/categories?post=17155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/tags?post=17155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}