{"id":4175,"date":"2024-08-05T03:41:18","date_gmt":"2024-08-05T03:41:18","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=4175"},"modified":"2024-08-05T03:41:18","modified_gmt":"2024-08-05T03:41:18","slug":"first-woman-cured-of-hiv-using-umbilical-cord-blood","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/cs\/science\/medical-research\/first-woman-cured-of-hiv-using-umbilical-cord-blood\/","title":{"rendered":"Prvn\u00ed \u017eena vyl\u00e9\u010den\u00e1 z HIV pomoc\u00ed pupe\u010dn\u00edkov\u00e9 krve"},"content":{"rendered":"

Prvn\u00ed \u017eena vyl\u00e9\u010den\u00e1 z HIV pomoc\u00ed pupe\u010dn\u00edkov\u00e9 krve<\/h2>\n\n

Pr\u016flomov\u00e1 l\u00e9\u010dba nab\u00edz\u00ed nad\u011bji r\u016fzn\u00fdm skupin\u00e1m pacient\u016f<\/h2>\n\n

V pozoruhodn\u00e9m l\u00e9ka\u0159sk\u00e9m pr\u016flomu se \u017eena sm\u00ed\u0161en\u00e9 rasy stala t\u0159et\u00ed osobou na sv\u011bt\u011b, o kter\u00e9 se p\u0159edpokl\u00e1d\u00e1, \u017ee byla vyl\u00e9\u010dena z HIV pot\u00e9, co dostala transplantaci kmenov\u00fdch bun\u011bk od d\u00e1rce, kter\u00fd je p\u0159irozen\u011b odoln\u00fd v\u016f\u010di viru. Tato inovativn\u00ed l\u00e9\u010dba pomoc\u00ed pupe\u010dn\u00edkov\u00e9 krve nab\u00edz\u00ed v\u00fdznamn\u00e9 v\u00fdhody oproti tradi\u010dn\u00edm transplantac\u00edm kostn\u00ed d\u0159en\u011b.<\/p>\n\n

Pupe\u010dn\u00edkov\u00e1 krev: M\u00e9n\u011b invazivn\u00ed mo\u017enost<\/h2>\n\n

Pupe\u010dn\u00edkov\u00e1 krev, odebran\u00e1 v dob\u011b narozen\u00ed d\u00edt\u011bte, obsahuje dosp\u011bl\u00e9 hematopoetick\u00e9 kmenov\u00e9 bu\u0148ky, kter\u00e9 se mohou vyvinout do v\u0161ech typ\u016f krevn\u00edch bun\u011bk nezbytn\u00fdch pro imunitn\u00ed syst\u00e9m. Na rozd\u00edl od transplantac\u00ed kostn\u00ed d\u0159en\u011b, kter\u00e9 vy\u017eaduj\u00ed \u00fazkou shodu mezi d\u00e1rcem a p\u0159\u00edjemcem, d\u00e1rci pupe\u010dn\u00edkov\u00e9 krve nemus\u00ed b\u00fdt tak \u00fazce shodn\u00ed, co\u017e z n\u00ed \u010din\u00ed dostupn\u011bj\u0161\u00ed mo\u017enost pro pacienty s neobvykl\u00fdmi typy tk\u00e1n\u00ed.<\/p>\n\n

V\u00fdhody pro pacienty sm\u00ed\u0161en\u00e9 rasy a \u017eeny<\/h2>\n\n

\u00dasp\u011b\u0161n\u00e1 l\u00e9\u010dba \u017eeny sm\u00ed\u0161en\u00e9 rasy pupe\u010dn\u00edkovou krv\u00ed je obzvl\u00e1\u0161t\u011b v\u00fdznamn\u00e1, proto\u017ee HIV ne\u00fam\u011brn\u011b postihuje rasov\u00e9 a etnick\u00e9 men\u0161iny. Nav\u00edc skute\u010dnost, \u017ee pacientka je \u017eena, zd\u016fraz\u0148uje potenci\u00e1ln\u00ed v\u00fdhody t\u00e9to l\u00e9\u010dby pro \u017eeny, kter\u00e9 jsou v klinick\u00fdch testech \u010dasto nedostate\u010dn\u011b zastoupeny.<\/p>\n\n

Sou\u010dasn\u00e1 l\u00e9\u010dba HIV a rakoviny<\/h2>\n\n

V\u0161ichni t\u0159i pacienti, u nich\u017e byla zjevn\u011b vyl\u00e9\u010dena HIV pomoc\u00ed transplantac\u00ed kmenov\u00fdch bun\u011bk, m\u011bli tak\u00e9 rakovinu a pot\u0159ebovali transplantace, aby jim zachr\u00e1nili \u017eivot. To nazna\u010duje, \u017ee transplantace pupe\u010dn\u00edkov\u00e9 krve m\u016f\u017ee nab\u00eddnout dvoj\u00ed v\u00fdhodu pacient\u016fm, kte\u0159\u00ed \u010del\u00ed jak HIV, tak agresivn\u00edm typ\u016fm rakoviny, jako je leuk\u00e9mie.<\/p>\n\n

V\u00fdzkum a dostupnost<\/h2>\n\n

Ned\u00e1vn\u00e1 l\u00e9\u010dba je sou\u010d\u00e1st\u00ed v\u011bt\u0161\u00ed studie, kter\u00e1 bude sledovat celkem 25 lid\u00ed s HIV, kte\u0159\u00ed dostanou transplantace kmenov\u00fdch bun\u011bk z pupe\u010dn\u00edkov\u00e9 krve k l\u00e9\u010db\u011b sv\u00e9 rakoviny. A\u010dkoli je l\u00e9\u010dba slibn\u00e1, zat\u00edm nen\u00ed \u0161iroce dostupn\u00e1 a pravd\u011bpodobn\u011b se zpo\u010d\u00e1tku bude t\u00fdkat pouze osob s agresivn\u00edmi typy rakoviny.<\/p>\n\n

Potenci\u00e1l pro \u0161ir\u0161\u00ed dopad<\/h2>\n\n

Navzdory sou\u010dasn\u00fdm omezen\u00edm m\u016f\u017ee m\u00edt \u00fasp\u011bch t\u00e9to l\u00e9\u010dby transforma\u010dn\u00ed dopad na \u017eivoty milion\u016f lid\u00ed \u017eij\u00edc\u00edch s HIV po cel\u00e9m sv\u011bt\u011b. V\u00fdzkumn\u00edci odhaduj\u00ed, \u017ee p\u0159ibli\u017en\u011b 50 pacient\u016f ro\u010dn\u011b v USA by mohlo m\u00edt prosp\u011bch z t\u00e9to procedury a mo\u017enost pou\u017e\u00edt \u010d\u00e1ste\u010dn\u011b shodn\u00e9 \u0161t\u011bpy pupe\u010dn\u00edkov\u00e9 krve v\u00fdrazn\u011b zvy\u0161uje pravd\u011bpodobnost nalezen\u00ed vhodn\u00fdch d\u00e1rc\u016f pro takov\u00e9 pacienty.<\/p>\n\n

Budouc\u00ed sm\u011bry<\/h2>\n\n

Prob\u00edhaj\u00edc\u00ed v\u00fdzkum se zam\u011b\u0159\u00ed na optimalizaci l\u00e9\u010debn\u00e9ho re\u017eimu, roz\u0161\u00ed\u0159en\u00ed krit\u00e9ri\u00ed zp\u016fsobilosti pacient\u016f a zp\u0159\u00edstupn\u011bn\u00ed postupu \u0161ir\u0161\u00ed ve\u0159ejnosti. S pokra\u010duj\u00edc\u00edm v\u00fdvojem m\u00e1 transplantace pupe\u010dn\u00edkov\u00e9 krve potenci\u00e1l st\u00e1t se \u017eivot zachra\u0148uj\u00edc\u00ed mo\u017enost\u00ed pro rostouc\u00ed po\u010det osob, kter\u00e9 \u010del\u00ed jak HIV, tak rakovin\u011b.<\/p>","protected":false},"excerpt":{"rendered":"

Prvn\u00ed \u017eena vyl\u00e9\u010den\u00e1 z HIV pomoc\u00ed pupe\u010dn\u00edkov\u00e9 krve Pr\u016flomov\u00e1 l\u00e9\u010dba nab\u00edz\u00ed nad\u011bji r\u016fzn\u00fdm skupin\u00e1m pacient\u016f V pozoruhodn\u00e9m l\u00e9ka\u0159sk\u00e9m pr\u016flomu se \u017eena sm\u00ed\u0161en\u00e9 rasy stala t\u0159et\u00ed osobou na sv\u011bt\u011b, o kter\u00e9…<\/p>\n","protected":false},"author":1,"featured_media":24007,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1862],"tags":[4788,3369,7663,6334,7662,7009],"class_list":["post-4175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-research","tag-hiv","tag-cancer-treatment","tag-mixed-race","tag-stem-cell-transplant","tag-umbilical-cord-blood","tag-womens-health"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/4175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/comments?post=4175"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/4175\/revisions"}],"predecessor-version":[{"id":4176,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/posts\/4175\/revisions\/4176"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/media\/24007"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/media?parent=4175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/categories?post=4175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/cs\/wp-json\/wp\/v2\/tags?post=4175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}