{"id":12601,"date":"2021-08-19T10:17:24","date_gmt":"2021-08-19T10:17:24","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=12601"},"modified":"2021-08-19T10:17:24","modified_gmt":"2021-08-19T10:17:24","slug":"proteins-reveal-hidden-stories-in-1630-plague-death-registry","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/tr\/science\/history-of-science\/proteins-reveal-hidden-stories-in-1630-plague-death-registry\/","title":{"rendered":"1630 Veba \u00d6l\u00fcm Kay\u0131tlar\u0131ndaki Gizli Hikayeler Proteinlerle Ortaya \u00c7\u0131k\u0131yor"},"content":{"rendered":"

Proteinler, 1630 Veba \u00d6l\u00fcm Kay\u0131tlar\u0131ndaki Gizli Hikayeleri Ortaya \u00c7\u0131kar\u0131yor<\/h2>\n\n

Tarihi Belgelerin Protein Analizi<\/h2>\n\n

As\u0131rlar boyunca veba Avrupa’y\u0131 kas\u0131p kavurdu ve ard\u0131ndan y\u0131k\u0131m b\u0131rakt\u0131. \u015eimdi bilim insanlar\u0131, tarihi belgelerden protein \u00e7\u0131karmak i\u00e7in \u00e7\u0131\u011f\u0131r a\u00e7an bir teknik ke\u015ffettiler ve bu sayede bu \u00e7alkant\u0131l\u0131 d\u00f6nemlerde ya\u015fam\u0131\u015f insanlar\u0131n hayatlar\u0131na dair yeni bilgiler elde edildi.<\/p>\n\n

Proteomik Teknolojisi<\/h2>\n\n

Proteinlerin incelenmesi olan proteomik, tarihi eserlerin analizinde devrim yaratt\u0131. Zamanla bozulan DNA’n\u0131n aksine proteinler daha stabildir ve belgeleri ele alan \u00e7evre ve ki\u015filer hakk\u0131nda de\u011ferli bilgiler sa\u011flayabilir.<\/p>\n\n

EVA Diskleri ve Protein \u00c7\u0131karma<\/h2>\n\n

Ara\u015ft\u0131rmac\u0131lar, ka\u011f\u0131t tabanl\u0131 belgelere yerle\u015ftirilerek protein par\u00e7alar\u0131n\u0131n \u00e7\u0131kar\u0131lmas\u0131n\u0131 sa\u011flayan etil vinilasetat (EVA) diskler geli\u015ftirdiler. Bu par\u00e7alar daha sonra k\u00fctle spektrometrisi kullan\u0131larak analiz edilir ve proteinler ile kaynaklar\u0131 belirlenir.<\/p>\n\n

1630 Milano Veba \u00d6l\u00fcm Kayd\u0131<\/h2>\n\n

\u00c7\u0131\u011f\u0131r a\u00e7an bir \u00e7al\u0131\u015fmada bilim insanlar\u0131, proteomi\u011fi 1630 Milano Veba \u00d6l\u00fcm Kayd\u0131’na uygulad\u0131lar. Bu titiz kay\u0131t, y\u0131k\u0131c\u0131 salg\u0131n s\u0131ras\u0131nda hayat\u0131n\u0131 kaybeden ki\u015filerin isimlerini ve ya\u015flar\u0131n\u0131 i\u00e7eriyordu.<\/p>\n\n

\u00c7evresel Ko\u015fullar<\/h2>\n\n

Kay\u0131tta bulunan proteinleri analiz ederek ara\u015ft\u0131rmac\u0131lar, veba s\u0131ras\u0131nda \u00e7evresel ko\u015fullar hakk\u0131nda bilgiler edindiler. Kemirgenlerin, bakterilerin ve katipler ve belgeyi ele alan di\u011fer ki\u015filer taraf\u0131ndan t\u00fcketilen besin kaynaklar\u0131n\u0131n varl\u0131\u011f\u0131n\u0131 tespit ettiler.<\/p>\n\n

Katiplerin Beslenmesi ve Hayvanlar\u0131n Varl\u0131\u011f\u0131<\/h2>\n\n

Protein analizi, katiplerin \u00e7o\u011funlukla m\u0131s\u0131r, patates, nohut, pirin\u00e7 ve havu\u00e7 t\u00fcketti\u011fini ortaya \u00e7\u0131kard\u0131. Koyun ve ke\u00e7i proteinlerinin varl\u0131\u011f\u0131, bu hayvanlar\u0131n muhtemelen vebaya yenik d\u00fc\u015fen annelerin bebeklerine yiyecek sa\u011flamak i\u00e7in karantina lazaretinde tutuldu\u011funu d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n

Bakteriyel Kirlilik<\/h2>\n\n

Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca, bubonik veba bakterisini i\u00e7eren Yersinia bakteri ailesine ait proteinler tespit ettiler. Bununla birlikte, bu proteinlerin insanlara zararl\u0131 olmayan di\u011fer Yersinia t\u00fcrlerine de ait olabilece\u011fini belirttiler.<\/p>\n\n

Zorluklar ve F\u0131rsatlar<\/h2>\n\n

Proteomik, tarihi ara\u015ft\u0131rmalar i\u00e7in heyecan verici olanaklar sunsa da baz\u0131 zorluklar da beraberinde getirmektedir. Protein dizilerini belirlemek karma\u015f\u0131k olabilir ve modern kaynaklardan kaynaklanan kirlilik bir endi\u015fe kayna\u011f\u0131 olabilir. Yine de ara\u015ft\u0131rmac\u0131lar, bu teknolojinin say\u0131s\u0131z tarihi belgedeki gizli hikayeleri ortaya \u00e7\u0131karma potansiyeline sahip oldu\u011funa inan\u0131yor.<\/p>\n\n

Tarih\u00e7iler \u0130\u00e7in \u00d6nemi<\/h2>\n\n

1630 Milano Veba \u00d6l\u00fcm Kayd\u0131’n\u0131n proteomik analizi, bu y\u0131k\u0131c\u0131 salg\u0131na g\u00f6\u011f\u00fcs gerenlerin hayatlar\u0131 hakk\u0131nda de\u011ferli bilgiler sa\u011fl\u0131yor. \u00c7evresel ko\u015fullar\u0131 yeniden yap\u0131land\u0131r\u0131yor, beslenme ve hayvan varl\u0131\u011f\u0131na \u0131\u015f\u0131k tutuyor ve b\u00fcy\u00fck bir \u00e7alkant\u0131 d\u00f6neminde bireylerin kar\u015f\u0131la\u015ft\u0131\u011f\u0131 zorluklar\u0131 ortaya koyuyor.<\/p>\n\n

K\u00fclt\u00fcrel Miras Ara\u015ft\u0131rmalar\u0131nda Uygulamalar<\/h2>\n\n

Veba \u00e7al\u0131\u015fmas\u0131n\u0131n \u00f6tesinde, proteomi\u011fin k\u00fclt\u00fcrel miras ara\u015ft\u0131rmalar\u0131nda geni\u015f uygulamalar\u0131 vard\u0131r. Yazarlar\u0131n orijinal belgelerini ara\u015ft\u0131rmak, yaz\u0131m s\u0131ras\u0131nda kullan\u0131lan ila\u00e7lar\u0131n veya t\u0131bbi durumlar\u0131n varl\u0131\u011f\u0131n\u0131 belirlemek ve orta \u00e7a\u011f el yazmalar\u0131nda gizli bilgileri ortaya \u00e7\u0131karmak i\u00e7in kullan\u0131labilir.<\/p>\n\n

Ge\u00e7mi\u015fi Ortaya \u00c7\u0131karmak<\/h2>\n\n

Ara\u015ft\u0131rmac\u0131lar proteomik teknolojisini geli\u015ftirmeye devam ettik\u00e7e, ge\u00e7mi\u015fi daha da derinlemesine anlamam\u0131z bekleniyor. Tarihi belgelerde g\u00f6m\u00fcl\u00fc proteinleri analiz ederek, bizden \u00f6nce gelenlerin hayatlar\u0131n\u0131, \u00e7evrelerini ve deneyimlerini yeniden olu\u015fturabilir ve insanl\u0131k tarihinin bilgisini zenginle\u015ftirebiliriz.<\/p>","protected":false},"excerpt":{"rendered":"

Proteinler, 1630 Veba \u00d6l\u00fcm Kay\u0131tlar\u0131ndaki Gizli Hikayeleri Ortaya \u00c7\u0131kar\u0131yor Tarihi Belgelerin Protein Analizi As\u0131rlar boyunca veba Avrupa’y\u0131 kas\u0131p kavurdu ve ard\u0131ndan y\u0131k\u0131m b\u0131rakt\u0131. \u015eimdi bilim insanlar\u0131, tarihi belgelerden protein \u00e7\u0131karmak…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[61],"tags":[17026,295,17027,89,17025,4641,3995],"class_list":["post-12601","post","type-post","status-publish","format-standard","hentry","category-history-of-science","tag-environmental-reconstruction","tag-diet","tag-animal-presence","tag-cultural-heritage","tag-proteomics","tag-historical-documents","tag-plague"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/comments?post=12601"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12601\/revisions"}],"predecessor-version":[{"id":12602,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12601\/revisions\/12602"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/media?parent=12601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/categories?post=12601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/tags?post=12601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}