{"id":12658,"date":"2022-05-26T04:53:16","date_gmt":"2022-05-26T04:53:16","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=12658"},"modified":"2022-05-26T04:53:16","modified_gmt":"2022-05-26T04:53:16","slug":"mini-brains-eye-like-features-retinal-disease-research","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/tr\/science\/biomedical-research\/mini-brains-eye-like-features-retinal-disease-research\/","title":{"rendered":"G\u00f6z Benzeri \u00d6zelliklere Sahip Mini Beyinler: Retina Hastal\u0131klar\u0131 Ara\u015ft\u0131rmalar\u0131nda Bir At\u0131l\u0131m"},"content":{"rendered":"<h2 class=\"wp-block-heading\">G\u00f6z Benzeri \u00d6zelliklere Sahip Mini Beyinler: Retina Hastal\u0131klar\u0131 Ara\u015ft\u0131rmalar\u0131nda Bir At\u0131l\u0131m<\/h2>\n\n<h2 class=\"wp-block-heading\">G\u00f6z Geli\u015fimini Anlamak<\/h2>\n\n<p>G\u00f6zlerin nas\u0131l geli\u015fti\u011fini anlamak, erken d\u00f6nem retina hastal\u0131klar\u0131n\u0131n gizemlerini \u00e7\u00f6zmeye \u00e7al\u0131\u015fan ara\u015ft\u0131rmac\u0131lar i\u00e7in \u00e7ok \u00f6nemlidir. Son zamanlarda yap\u0131lan bir \u00e7al\u0131\u015fma, optik kap ad\u0131 verilen g\u00f6z benzeri olu\u015fumlarla minyat\u00fcr beyinler yeti\u015ftirerek bu alanda \u00f6nemli ilerlemeler kaydetti. Bu optik kaplar, retinan\u0131n \u00f6nc\u00fcleri olup, mini organoidler i\u00e7inde geli\u015fmeleri, insan embriyosundaki g\u00f6z yap\u0131lar\u0131n\u0131n ortaya \u00e7\u0131k\u0131\u015f\u0131na \u00e7ok benzemektedir.<\/p>\n\n<h2 class=\"wp-block-heading\">Organoidler: Organlar\u0131 Laboratuvar ortam\u0131nda kopyalamak<\/h2>\n\n<p>Organoidler, organlar\u0131n yap\u0131s\u0131n\u0131 ve i\u015flevini taklit eden, k\u00fc\u00e7\u00fck, \u00fc\u00e7 boyutlu doku k\u00fclt\u00fcrleridir. Ara\u015ft\u0131rmac\u0131lar, v\u00fccuttaki herhangi bir h\u00fccreye d\u00f6n\u00fc\u015fme potansiyeline sahip k\u00f6k h\u00fccrelerden minik organoidler olu\u015ftururlar. Organoidleri incelemek, bilim insanlar\u0131n\u0131n organlar\u0131n nas\u0131l geli\u015fti\u011fini ve \u00e7e\u015fitli tedavilere nas\u0131l tepki verdi\u011fini g\u00f6zlemlemelerine olanak tan\u0131r.<\/p>\n\n<h2 class=\"wp-block-heading\">iPSC&#8217;den Yeti\u015ftirilen Mini Beyinler<\/h2>\n\n<p>Bu \u00e7\u0131\u011f\u0131r a\u00e7an \u00e7al\u0131\u015fmada, ara\u015ft\u0131rmac\u0131lar mini beyinleri yeti\u015ftirmek i\u00e7in insan kaynakl\u0131 pluripotent k\u00f6k h\u00fccreler (iPSC&#8217;ler) kulland\u0131lar. iPSC&#8217;ler, insan embriyolar\u0131ndan elde edilen yeti\u015fkin k\u00f6k h\u00fccrelerdir. Bununla birlikte, geleneksel embriyonik k\u00f6k h\u00fccrelerin aksine, iPSC&#8217;ler tipik olarak cilt veya kan \u00f6rneklerinden al\u0131nan yeti\u015fkin insan h\u00fccrelerinden elde edilir. Bu h\u00fccreler daha sonra embriyonik benzeri bir duruma yeniden programlan\u0131r ve v\u00fccuttaki herhangi bir h\u00fccreye d\u00f6n\u00fc\u015fmelerini sa\u011flar.<\/p>\n\n<h2 class=\"wp-block-heading\">Optik Kaplar\u0131n Geli\u015ftirilmesi<\/h2>\n\n<p>\u00d6nceki ara\u015ft\u0131rma \u00e7al\u0131\u015fmalar\u0131, ya saf retina h\u00fccreleri ya da optik kaplar\u0131 izole bir \u015fekilde b\u00fcy\u00fctmeye odaklanm\u0131\u015ft\u0131. Ancak bu \u00e7al\u0131\u015fma, optik kaplar\u0131 mini beyinlerin bir par\u00e7as\u0131 olarak b\u00fcy\u00fcterek entegre bir sistem olu\u015fturmay\u0131 ama\u00e7lad\u0131. Ara\u015ft\u0131rmac\u0131lar, k\u00f6k h\u00fccreleri sinir dokusuna d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in kullan\u0131lan bir tekni\u011fi de\u011fi\u015ftirerek bu hedefe ula\u015ft\u0131lar.<\/p>\n\n<p>H\u00fccreler mini beyinlere d\u00f6n\u00fc\u015ft\u00fckten sonra, optik kaplar 30 g\u00fcn i\u00e7inde ortaya \u00e7\u0131kt\u0131 ve 50. g\u00fcnde tamamen olgunla\u015ft\u0131. Bu geli\u015fimin zamanlamas\u0131, insan embriyosundaki g\u00f6z geli\u015fimiyle uyumludur ve bu s\u00fcrecin g\u00f6z geli\u015fimini rahim i\u00e7inde incelemek i\u00e7in kullan\u0131labilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n<h2 class=\"wp-block-heading\">I\u015f\u0131\u011fa Duyarl\u0131 ve Karma\u015f\u0131k Yap\u0131lar<\/h2>\n\n<p>Dikkat \u00e7ekici bir \u015fekilde, mini beyinlerdeki optik kaplar \u0131\u015f\u0131\u011fa duyarl\u0131l\u0131k g\u00f6sterdi ve n\u00f6ron dokusuna ba\u011fl\u0131 \u00e7e\u015fitli retina h\u00fccre tipleri geli\u015ftirdiler. Organoidlerdeki g\u00f6zler lens ve kornea dokusu bile i\u00e7eriyordu.<\/p>\n\n<h2 class=\"wp-block-heading\">Potansiyel Uygulamalar<\/h2>\n\n<p>G\u00f6z benzeri \u00f6zelliklere sahip mini beyinlerin geli\u015ftirilmesi, retina hastal\u0131klar\u0131 ara\u015ft\u0131rmalar\u0131 ve tedavisi i\u00e7in \u00e7ok y\u00f6nl\u00fc etkilere sahiptir. Bu organoidler bilim insanlar\u0131n\u0131n \u015funlar\u0131 yapmas\u0131na yard\u0131mc\u0131 olabilir:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Embriyonik geli\u015fim s\u0131ras\u0131nda beyin-g\u00f6z etkile\u015fimlerini incelemek<\/li>\n<li>Do\u011fu\u015ftan gelen retina bozukluklar\u0131n\u0131 modellemek<\/li>\n<li>Ki\u015fiye \u00f6zel ila\u00e7 testleri i\u00e7in hasta \u00f6zelinde retina h\u00fccre tipleri olu\u015fturmak<\/li>\n<li>Retina hastal\u0131klar\u0131 i\u00e7in nakil terapileri geli\u015ftirmek<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Gelecekteki Y\u00f6nler<\/h2>\n\n<p>Bilim insanlar\u0131 \u015fu anda, retina bozukluklar\u0131n\u0131n daha derinlemesine incelenmesini kolayla\u015ft\u0131rmak i\u00e7in optik kaplar\u0131n \u00f6mr\u00fcn\u00fc uzatman\u0131n yollar\u0131n\u0131 ara\u015ft\u0131r\u0131yorlar. Bu ara\u015ft\u0131rma, g\u00f6z geli\u015fimi anlay\u0131\u015f\u0131m\u0131z\u0131 ilerletme ve retina hastal\u0131klar\u0131 i\u00e7in yeni tedavilerin yolunu a\u00e7ma konusunda b\u00fcy\u00fck bir potansiyele sahiptir.<\/p>","protected":false},"excerpt":{"rendered":"<p>G\u00f6z Benzeri \u00d6zelliklere Sahip Mini Beyinler: Retina Hastal\u0131klar\u0131 Ara\u015ft\u0131rmalar\u0131nda Bir At\u0131l\u0131m G\u00f6z Geli\u015fimini Anlamak G\u00f6zlerin nas\u0131l geli\u015fti\u011fini anlamak, erken d\u00f6nem retina hastal\u0131klar\u0131n\u0131n gizemlerini \u00e7\u00f6zmeye \u00e7al\u0131\u015fan ara\u015ft\u0131rmac\u0131lar i\u00e7in \u00e7ok \u00f6nemlidir. Son&hellip;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3713],"tags":[1867,17086,16118,17085,1579,17084,17083,2112],"class_list":["post-12658","post","type-post","status-publish","format-standard","hentry","category-biomedical-research","tag-biotechnology","tag-eye-development","tag-stem-cells","tag-mini-brains","tag-neuroscience","tag-organoids","tag-retinal-disease","tag-medical-research"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/comments?post=12658"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12658\/revisions"}],"predecessor-version":[{"id":12659,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/12658\/revisions\/12659"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/media?parent=12658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/categories?post=12658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/tags?post=12658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}