Melanom, en tehlikeli deri kanseri t\u00fcr\u00fcd\u00fcr ve bu hastal\u0131ktan kaynaklanan \u00f6l\u00fcmlerin b\u00fcy\u00fck \u00e7o\u011funlu\u011funu olu\u015fturur. Melanom i\u00e7in geleneksel tedaviler aras\u0131nda cerrahi, kemoterapi ve radyoterapi bulunur. Ancak bu tedaviler \u00f6nemli yan etkiler g\u00f6sterebilir ve n\u00fcks\u00fcn \u00f6nlenmesinde her zaman etkili olmayabilir.<\/p>\n\n
mRNA a\u015f\u0131lar\u0131, kanser dahil olmak \u00fczere \u00e7e\u015fitli hastal\u0131klar\u0131n \u00f6nlenmesi ve tedavisinde umut vaat eden yeni bir a\u015f\u0131 t\u00fcr\u00fcd\u00fcr. mRNA a\u015f\u0131lar\u0131, v\u00fccuttaki h\u00fccrelere mesajc\u0131 RNA (mRNA) g\u00f6ndererek \u00e7al\u0131\u015f\u0131r; bu mRNA, h\u00fccreleri bir protein \u00fcretmeye y\u00f6nlendirir ve bu protein ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131 tetikler.<\/p>\n\n
Ara\u015ft\u0131rmac\u0131lar, her hastan\u0131n t\u00fcm\u00f6r\u00fcne \u00f6zel olarak tasarlanm\u0131\u015f ki\u015fiselle\u015ftirilmi\u015f bir mRNA a\u015f\u0131s\u0131 geli\u015ftirdi. A\u015f\u0131, hastan\u0131n ameliyat s\u0131ras\u0131nda \u00e7\u0131kar\u0131lan t\u00fcm\u00f6r h\u00fccreleri kullan\u0131larak haz\u0131rlan\u0131r. Bu t\u00fcm\u00f6r h\u00fccreleri, y\u00fczeylerinde bulunan benzersiz neoantijenleri belirlemek i\u00e7in analiz edilir. Neoantijenler, kanser h\u00fccrelerinde bulunup sa\u011fl\u0131kl\u0131 h\u00fccrelerde yer almayan proteinlerdir.<\/p>\n\n
Ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131s\u0131, hastan\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemine bu neoantijenleri tan\u0131mas\u0131 ve onlara sald\u0131rmas\u0131 \u00f6\u011fretilir. Birden fazla neoantijeni hedef alarak, a\u015f\u0131 daha g\u00fc\u00e7l\u00fc ve etkili bir ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 olu\u015fturabilir.<\/p>\n\n
Ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131s\u0131n\u0131n melanoma \u00fczerindeki faz 2 \u00e7al\u0131\u015fmas\u0131 yak\u0131n zamanda yap\u0131ld\u0131 ve sonu\u00e7lar Amerikan Kanser Ara\u015ft\u0131rmalar\u0131 Derne\u011fi (AACR) toplant\u0131s\u0131nda sunuldu. \u00c7al\u0131\u015fmaya, ameliyatla t\u00fcm\u00f6rleri \u00e7\u0131kar\u0131lm\u0131\u015f y\u00fcksek riskli melanoma hastalar\u0131 olan 157 ki\u015fi dahil edildi.<\/p>\n\n
Hasta gruplar\u0131, ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131s\u0131 ile immunoterapi ilac\u0131 Keytruda\u2019n\u0131n kombinasyonu ya da yaln\u0131zca Keytruda alacak \u015fekilde rastgele atand\u0131. Sonu\u00e7lar, a\u015f\u0131 ve Keytruda kombinasyonunun, yaln\u0131zca Keytruda\u2019ya k\u0131yasla n\u00fcks\u00fcn \u00f6nlenmesinde anlaml\u0131 derecede daha etkili oldu\u011funu g\u00f6sterdi.<\/p>\n\n
\u00d6zellikle iki y\u0131l i\u00e7inde kanser, yaln\u0131zca Keytruda alan hastalar\u0131n %40\u2019\u0131nda yeniden ortaya \u00e7\u0131kt\u0131. Ancak her iki tedaviyi de alan hastalar\u0131n sadece %22\u2019sinde n\u00fcks g\u00f6r\u00fcld\u00fc. Bu, a\u015f\u0131 kullan\u0131m\u0131n\u0131n, Keytruda tek ba\u015f\u0131na verilen tedaviye g\u00f6re n\u00fcks veya \u00f6l\u00fcm riskini %44 azaltt\u0131\u011f\u0131 anlam\u0131na geliyor.<\/p>\n\n
Bu faz 2 \u00e7al\u0131\u015fmas\u0131n\u0131n sonu\u00e7lar\u0131 \u00e7ok umut verici ve ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131n\u0131n melanoma tedavisinde b\u00fcy\u00fck bir at\u0131l\u0131m olabilece\u011fini g\u00f6steriyor. A\u015f\u0131 iyi tolere ediliyor ve \u00f6l\u00fcmc\u00fcl bu hastal\u0131\u011fa sahip hastalar\u0131n sonu\u00e7lar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirme potansiyeline sahip.<\/p>\n\n
Ara\u015ft\u0131rmac\u0131lar, melanoma i\u00e7in ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131n\u0131n faz 3 \u00e7al\u0131\u015fmas\u0131n\u0131 planl\u0131yor. Bu \u00e7al\u0131\u015fma, daha b\u00fcy\u00fck bir hasta say\u0131s\u0131n\u0131 i\u00e7erecek ve a\u015f\u0131n\u0131n g\u00fcvenlik ve etkinli\u011fini daha ayr\u0131nt\u0131l\u0131 olarak de\u011ferlendirecek. Faz 3 \u00e7al\u0131\u015fmas\u0131 ba\u015far\u0131l\u0131 olursa, a\u015f\u0131 \u00fc\u00e7 y\u0131l i\u00e7inde onay alabilir.<\/p>\n\n
Melanom i\u00e7in ki\u015fiselle\u015ftirilmi\u015f mRNA a\u015f\u0131n\u0131n geli\u015ftirilmesi, bu \u00f6l\u00fcmc\u00fcl hastal\u0131\u011fa kar\u015f\u0131 m\u00fccadelede b\u00fcy\u00fck bir ilerleme anlam\u0131na geliyor. A\u015f\u0131, erken klinik denemelerde umut verici sonu\u00e7lar g\u00f6sterdi ve ara\u015ft\u0131rmac\u0131lar, eventual olarak hastalarda kullan\u0131ma onay al\u0131nmas\u0131n\u0131 umuyor.<\/p>","protected":false},"excerpt":{"rendered":"
Ki\u015fiselle\u015ftirilmi\u015f mRNA A\u015f\u0131s\u0131 Melanomda \u00dcmit Veriyor Arka Plan Melanom, en tehlikeli deri kanseri t\u00fcr\u00fcd\u00fcr ve bu hastal\u0131ktan kaynaklanan \u00f6l\u00fcmlerin b\u00fcy\u00fck \u00e7o\u011funlu\u011funu olu\u015fturur. Melanom i\u00e7in geleneksel tedaviler aras\u0131nda cerrahi, kemoterapi ve…<\/p>\n","protected":false},"author":2,"featured_media":25581,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359],"tags":[18523,18526,3368,5613,18525,18522,18524,18527],"class_list":["post-13774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","tag-cancer-vaccine","tag-clinical-trial","tag-immunotherapy","tag-cancer-research","tag-personalized-medicine","tag-melanoma","tag-mrna-vaccine","tag-phase-2-trial"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/13774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/comments?post=13774"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/13774\/revisions"}],"predecessor-version":[{"id":25582,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/13774\/revisions\/25582"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/media\/25581"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/media?parent=13774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/categories?post=13774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/tags?post=13774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}