{"id":18301,"date":"2021-06-24T18:42:04","date_gmt":"2021-06-24T18:42:04","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=18301"},"modified":"2021-06-24T18:42:04","modified_gmt":"2021-06-24T18:42:04","slug":"invention-of-the-asthma-inhaler","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/tr\/science\/medicine\/invention-of-the-asthma-inhaler\/","title":{"rendered":"Ast\u0131m \u0130nhalerinin \u0130cad\u0131: Basit Bir Soru, Kronik Bir Hastal\u0131\u011f\u0131n Tedavisinde Devrim yaratt\u0131"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Ast\u0131m \u0130nhalerinin \u0130cad\u0131<\/h2>\n\n<h2 class=\"wp-block-heading\">\u0130lham<\/h2>\n\n<p>1955 y\u0131l\u0131nda, Susie Maison ad\u0131nda 13 ya\u015f\u0131nda bir k\u0131z, babas\u0131 George L. Maison&#8217;a, bir farmakologa, \u015fu basit soruyu y\u00f6neltti: &#8220;Ast\u0131m ilac\u0131m neden sa\u00e7 spreyi gibi bir sprey kutusunda olmas\u0131n?&#8221;<\/p>\n\n<h2 class=\"wp-block-heading\">Mucit<\/h2>\n\n<p>\u0130novasyon konusunda deneyimli olan Maison, k\u0131z\u0131n\u0131n \u00f6nerisini ciddiye ald\u0131. Riker Laboratories&#8217;\u0131n ba\u015fkan\u0131 olarak, ba\u015f kimyager Irving Porush&#8217;u bas\u0131n\u00e7l\u0131 bir inhaler cihaz\u0131 ihtimalini ara\u015ft\u0131rmakla g\u00f6revlendirdi.<\/p>\n\n<h2 class=\"wp-block-heading\">\u0130novasyon<\/h2>\n\n<p>Porush, Rexall Drugs&#8217;\u0131n (Riker&#8217;\u0131n ana \u015firketi) kozmetik teknisyenleriyle \u00e7al\u0131\u015farak itici gazlar ve aerosoller konusundaki uzmanl\u0131ktan faydaland\u0131. Ayr\u0131ca, atomize edilmi\u015f s\u0131v\u0131n\u0131n kesin miktarlar\u0131n\u0131 verebilen, yak\u0131n zamanda patentli bir \u00f6l\u00e7\u00fcm vanas\u0131 da dahil etti. \u0130ki ay i\u00e7inde Porush, ilk \u00f6l\u00e7\u00fcl\u00fc doz inhalerini (MDI) geli\u015ftirdi.<\/p>\n\n<h2 class=\"wp-block-heading\">FDA Onay\u0131<\/h2>\n\n<p>Mart 1956&#8217;da, G\u0131da ve \u0130la\u00e7 Dairesi (FDA), Porush&#8217;un MDI cihaz\u0131yla birlikte ast\u0131m i\u00e7in iki yeni aerosol ilac\u0131 onaylad\u0131.<\/p>\n\n<h2 class=\"wp-block-heading\">Ast\u0131m Tedavisine Etkisi<\/h2>\n\n<p>MDI, ast\u0131m tedavisinde devrim yaratt\u0131. Nebulizat\u00f6rler ve &#8220;ast\u0131m sigaralar\u0131&#8221; gibi \u00f6nceki y\u00f6ntemlerden daha kullan\u0131\u015fl\u0131 ve etkiliydi. G\u00fcn\u00fcm\u00fczde, farmas\u00f6tik inhalerler y\u0131ll\u0131k 36 milyar dolar\u0131 a\u015fan k\u00fcresel sat\u0131\u015flara ula\u015fm\u0131\u015ft\u0131r ve d\u00fcnya \u00e7ap\u0131nda milyonlarca insan her g\u00fcn onlara ba\u011f\u0131ml\u0131d\u0131r.<\/p>\n\n<h2 class=\"wp-block-heading\">\u0130novasyon Miras\u0131<\/h2>\n\n<p>Ast\u0131m inhaleri, inovasyonun g\u00fcc\u00fcne bir kan\u0131tt\u0131r. Basit bir sorudan ve bilim insanlar\u0131, m\u00fchendisler ve teknisyenlerin i\u015f birli\u011finden do\u011fmu\u015ftur. Ast\u0131m hastalar\u0131n\u0131n ya\u015famlar\u0131 \u00fczerindeki etkisi, ya\u015fam kalitelerini iyile\u015ftirerek ve durumlar\u0131n\u0131 etkili bir \u015fekilde y\u00f6netmelerini sa\u011flayarak derin olmu\u015ftur.<\/p>\n\n<h2 class=\"wp-block-heading\">\u00d6nemli Olaylar\u0131n Zaman \u00c7izelgesi<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>1955:<\/strong> Susie Maison, sprey kutulu bir ast\u0131m inhaleri \u00f6nerir.<\/li>\n<li><strong>1956:<\/strong> Irving Porush, ilk \u00f6l\u00e7\u00fcl\u00fc doz inhalerini (MDI) geli\u015ftirir.<\/li>\n<li><strong>1956:<\/strong> FDA, ast\u0131m i\u00e7in iki yeni aerosol ilac\u0131 ve MDI cihaz\u0131n\u0131 onaylar.<\/li>\n<li><strong>G\u00fcn\u00fcm\u00fcz:<\/strong> Farmas\u00f6tik inhalerler, y\u0131ll\u0131k 36 milyar dolar\u0131 a\u015fan k\u00fcresel sat\u0131\u015flarla ast\u0131m tedavisinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Ek Bilgiler<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>MDI&#8217;lar\u0131n \u00c7al\u0131\u015fma Prensibi:<\/strong> MDI&#8217;lar, bas\u0131n\u00e7l\u0131 bir aerosol yoluyla ila\u00e7lar\u0131 do\u011frudan akci\u011ferlere iletir. Genellikle bir itici gaz, bir ila\u00e7 ve dozu kontrol eden bir \u00f6l\u00e7\u00fcm vanas\u0131 i\u00e7erirler.<\/li>\n<li><strong>MDI T\u00fcrleri:<\/strong> \u0130ki ana MDI t\u00fcr\u00fc vard\u0131r: bas\u0131n\u00e7l\u0131 MDI&#8217;lar (pMDI&#8217;lar) ve kuru toz inhalerler (DPI&#8217;lar). pMDI&#8217;lar, bir ila\u00e7 sisi olu\u015fturmak i\u00e7in bir itici gaz kullan\u0131rken, DPI&#8217;lar ilac\u0131 da\u011f\u0131tmak i\u00e7in hastan\u0131n nefesini kullan\u0131r.<\/li>\n<li><strong>Ast\u0131m Y\u00f6netimi:<\/strong> \u0130nhalerler, ast\u0131m y\u00f6netiminin \u00f6nemli bir par\u00e7as\u0131d\u0131r. Ast\u0131m ataklar\u0131n\u0131 \u00f6nlemeye ve hafifletmeye, iltihab\u0131 azaltmaya ve akci\u011fer fonksiyonunu iyile\u015ftirmeye yard\u0131mc\u0131 olabilirler.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Ast\u0131m \u0130nhalerinin \u0130cad\u0131 \u0130lham 1955 y\u0131l\u0131nda, Susie Maison ad\u0131nda 13 ya\u015f\u0131nda bir k\u0131z, babas\u0131 George L. Maison&#8217;a, bir farmakologa, \u015fu basit soruyu y\u00f6neltti: &#8220;Ast\u0131m ilac\u0131m neden sa\u00e7 spreyi gibi bir&hellip;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359],"tags":[23943,15402,23944,8368,358],"class_list":["post-18301","post","type-post","status-publish","format-standard","hentry","category-medicine","tag-asthma","tag-pharmacology","tag-inhaler","tag-respiratory-health","tag-medical-innovation"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/18301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/comments?post=18301"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/18301\/revisions"}],"predecessor-version":[{"id":18302,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/posts\/18301\/revisions\/18302"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/media?parent=18301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/categories?post=18301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/tr\/wp-json\/wp\/v2\/tags?post=18301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}