{"id":11393,"date":"2024-10-27T09:53:10","date_gmt":"2024-10-27T09:53:10","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=11393"},"modified":"2024-10-27T09:53:10","modified_gmt":"2024-10-27T09:53:10","slug":"pig-heart-transplant-successes-and-challenges","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/medical-research\/pig-heart-transplant-successes-and-challenges\/","title":{"rendered":"Gh\u00e9p tim heo: Th\u00e0nh c\u00f4ng v\u00e0 th\u00e1ch th\u1ee9c"},"content":{"rendered":"

C\u1ea5y gh\u00e9p tim l\u1ee3n: Th\u00e0nh c\u00f4ng v\u00e0 Th\u00e1ch th\u1ee9c<\/h2>\n\n

Xenogh\u00e9p: M\u1ed9t gi\u1ea3i ph\u00e1p \u0111\u1ea7y tri\u1ec3n v\u1ecdng cho t\u00ecnh tr\u1ea1ng suy \u0111a c\u01a1 quan<\/h2>\n\n

Xenogh\u00e9p, vi\u1ec7c gh\u00e9p c\u00e1c c\u01a1 quan t\u1eeb lo\u00e0i n\u00e0y sang lo\u00e0i kh\u00e1c, h\u1ee9a h\u1eb9n s\u1ebd gi\u1ea3i quy\u1ebft t\u00ecnh tr\u1ea1ng thi\u1ebfu h\u1ee5t n\u1ed9i t\u1ea1ng ng\u01b0\u1eddi \u0111\u1ec3 gh\u00e9p. C\u1ea5y gh\u00e9p tim l\u1ee3n \u0111\u00e3 n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng cho nh\u1eefng b\u1ec7nh nh\u00e2n suy tim giai \u0111o\u1ea1n cu\u1ed1i.<\/p>\n\n

ca c\u1ea5y gh\u00e9p tim l\u1ee3n \u0111\u1ea7u ti\u00ean: M\u1ed9t s\u1ef1 ki\u1ec7n mang t\u00ednh b\u01b0\u1edbc ngo\u1eb7t<\/h2>\n\n

V\u00e0o th\u00e1ng 1 n\u0103m 2022, David Bennett, m\u1ed9t ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng 57 tu\u1ed5i b\u1ecb suy tim n\u1eb7ng, \u0111\u00e3 tr\u1ea3i qua ca gh\u00e9p tim l\u1ee3n \u0111\u1ea7u ti\u00ean tr\u00ean th\u1ebf gi\u1edbi. Tr\u00e1i tim l\u1ee3n \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gen ban \u0111\u1ea7u ho\u1ea1t \u0111\u1ed9ng t\u1ed1t, nh\u01b0ng t\u00ecnh tr\u1ea1ng c\u1ee7a Bennett x\u1ea5u \u0111i sau kho\u1ea3ng 40 ng\u00e0y. \u00d4ng qua \u0111\u1eddi v\u00e0o ng\u00e0y 8 th\u00e1ng 3 v\u00ec m\u1ed9t nguy\u00ean nh\u00e2n ch\u01b0a \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh.<\/p>\n\n

Cytomegalovirus \u1edf l\u1ee3n: M\u1ed9t th\u1ee7 ph\u1ea1m ti\u1ec1m t\u00e0ng<\/h2>\n\n

M\u1ed9t cu\u1ed9c \u0111i\u1ec1u tra \u0111\u00e3 ph\u00e1t hi\u1ec7n ra s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a Cytomegalovirus \u1edf l\u1ee3n (PCMV) trong con l\u1ee3n hi\u1ebfn t\u1eb7ng cho Bennett. PCMV l\u00e0 m\u1ed9t lo\u1ea1i vi-r\u00fat ti\u1ec1m \u1ea9n c\u00f3 th\u1ec3 v\u1eabn \u1edf tr\u1ea1ng th\u00e1i kh\u00f4ng ho\u1ea1t \u0111\u1ed9ng \u1edf l\u1ee3n nh\u01b0ng c\u00f3 th\u1ec3 t\u00e1i ho\u1ea1t \u0111\u1ed9ng v\u00e0 g\u00e2y b\u1ec7nh \u1edf ng\u01b0\u1eddi. C\u00e1c chuy\u00ean gia tin r\u1eb1ng PCMV c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong c\u00e1i ch\u1ebft c\u1ee7a Bennett.<\/p>\n\n

X\u00e9t nghi\u1ec7m s\u00e0ng l\u1ecdc m\u1ea7m b\u1ec7nh: Thi\u1ebft y\u1ebfu \u0111\u1ec3 ph\u00f2ng ng\u1eeba nhi\u1ec5m tr\u00f9ng<\/h2>\n\n

Con l\u1ee3n hi\u1ebfn t\u1eb7ng \u0111\u00e3 tr\u1ea3i qua qu\u00e1 tr\u00ecnh s\u00e0ng l\u1ecdc m\u1ea7m b\u1ec7nh, nh\u01b0ng c\u00e1c x\u00e9t nghi\u1ec7m t\u1eadp trung v\u00e0o c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng \u0111ang ho\u1ea1t \u0111\u1ed9ng v\u00e0 b\u1ecf s\u00f3t PCMV ti\u1ec1m \u1ea9n. \u0110i\u1ec1u n\u00e0y nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a vi\u1ec7c s\u00e0ng l\u1ecdc m\u1ea7m b\u1ec7nh to\u00e0n di\u1ec7n \u0111\u1ec3 gi\u1ea3m thi\u1ec3u nguy c\u01a1 nhi\u1ec5m tr\u00f9ng sau xenogh\u00e9p.<\/p>\n\n

Nh\u1eefng th\u00e1ch th\u1ee9c c\u1ee7a Xenogh\u00e9p<\/h2>\n\n

Ca gh\u00e9p tim l\u1ee3n \u0111\u1ea7u ti\u00ean \u0111\u00e3 ch\u1ee9ng minh c\u1ea3 ti\u1ec1m n\u0103ng v\u00e0 th\u00e1ch th\u1ee9c c\u1ee7a xenogh\u00e9p. Vi\u1ec7c truy\u1ec1n vi-r\u00fat t\u1eeb \u0111\u1ed9ng v\u1eadt sang ng\u01b0\u1eddi v\u1eabn l\u00e0 m\u1ed9t m\u1ed1i quan t\u00e2m l\u1edbn. Ngo\u00e0i ra, h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a con ng\u01b0\u1eddi c\u00f3 th\u1ec3 \u0111\u00e0o th\u1ea3i c\u00e1c c\u01a1 quan c\u1ee7a \u0111\u1ed9ng v\u1eadt, \u0111\u00f2i h\u1ecfi ph\u1ea3i d\u00f9ng thu\u1ed1c \u1ee9c ch\u1ebf mi\u1ec5n d\u1ecbch c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m tr\u00f9ng.<\/p>\n\n

T\u01b0\u01a1ng lai c\u1ee7a Xenogh\u00e9p<\/h2>\n\n

B\u1ea5t ch\u1ea5p nh\u1eefng th\u00e1ch th\u1ee9c, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn l\u1ea1c quan v\u1ec1 t\u01b0\u01a1ng lai c\u1ee7a xenogh\u00e9p. H\u1ecd \u0111ang nghi\u00ean c\u1ee9u \u0111\u1ec3 ph\u00e1t tri\u1ec3n nh\u1eefng ch\u00fa l\u1ee3n \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gen c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i vi-r\u00fat v\u00e0 \u00edt c\u00f3 kh\u1ea3 n\u0103ng b\u1ecb h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a con ng\u01b0\u1eddi \u0111\u00e0o th\u1ea3i. C\u0169ng c\u1ea7n ph\u1ea3i nghi\u00ean c\u1ee9u th\u00eam \u0111\u1ec3 c\u1ea3i thi\u1ec7n vi\u1ec7c s\u00e0ng l\u1ecdc m\u1ea7m b\u1ec7nh v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng vi-r\u00fat hi\u1ec7u qu\u1ea3.<\/p>\n\n

Nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m \u1ea9n c\u1ee7a C\u1ea5y gh\u00e9p tim l\u1ee3n<\/h2>\n\n

C\u1ea5y gh\u00e9p tim l\u1ee3n c\u00f3 th\u1ec3 c\u00e1ch m\u1ea1ng h\u00f3a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb suy tim. N\u1ebfu th\u00e0nh c\u00f4ng, ch\u00fang c\u00f3 th\u1ec3 cung c\u1ea5p m\u1ed9t ngu\u1ed3n n\u1ed9i t\u1ea1ng s\u1eb5n c\u00f3 cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 nhu c\u1ea7u, c\u00f3 kh\u1ea3 n\u0103ng c\u1ee9u s\u1ed1ng v\u00f4 s\u1ed1 ng\u01b0\u1eddi. Ngo\u00e0i ra, xenogh\u00e9p c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nhu c\u1ea7u hi\u1ebfn t\u1eb7ng n\u1ed9i t\u1ea1ng t\u1eeb ng\u01b0\u1eddi, gi\u1ea3m b\u1edbt nh\u1eefng lo ng\u1ea1i v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c li\u00ean quan \u0111\u1ebfn vi\u1ec7c l\u1ea5y n\u1ed9i t\u1ea1ng.<\/p>\n\n

Nh\u1eefng c\u00e2n nh\u1eafc v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c<\/h2>\n\n

Vi\u1ec7c s\u1eed d\u1ee5ng \u0111\u1ed9ng v\u1eadt l\u00e0m ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng n\u1ed9i t\u1ea1ng \u0111\u1eb7t ra nh\u1eefng lo ng\u1ea1i v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c, bao g\u1ed3m nguy c\u01a1 \u0111\u1ed9ng v\u1eadt b\u1ecb \u0111au \u0111\u1edbn v\u00e0 nh\u1eefng t\u00e1c \u0111\u1ed9ng \u0111\u1ebfn m\u1ed1i quan h\u1ec7 gi\u1eefa ng\u01b0\u1eddi v\u00e0 \u0111\u1ed9ng v\u1eadt. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i c\u00e2n nh\u1eafc nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m \u1ea9n c\u1ee7a xenogh\u00e9p so v\u1edbi nh\u1eefng c\u00e2n nh\u1eafc v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c n\u00e0y.<\/p>\n\n

Ph\u1ea7n k\u1ebft lu\u1eadn<\/h2>\n\n

Ca gh\u00e9p tim l\u1ee3n \u0111\u1ea7u ti\u00ean l\u00e0 m\u1ed9t s\u1ef1 ki\u1ec7n mang t\u00ednh \u0111\u1ed9t ph\u00e1, ch\u1ee9ng minh ti\u1ec1m n\u0103ng c\u1ee7a xenogh\u00e9p. Tuy nhi\u00ean, v\u1eabn c\u00f2n nh\u1eefng th\u00e1ch th\u1ee9c, bao g\u1ed3m nguy c\u01a1 nhi\u1ec5m tr\u00f9ng v\u00e0 \u0111\u00e0o th\u1ea3i. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00edch c\u1ef1c n\u1ed7 l\u1ef1c \u0111\u1ec3 v\u01b0\u1ee3t qua nh\u1eefng th\u00e1ch th\u1ee9c n\u00e0y v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c k\u1ef9 thu\u1eadt xenogh\u00e9p an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n. V\u1edbi nh\u1eefng nghi\u00ean c\u1ee9u li\u00ean t\u1ee5c v\u00e0 nh\u1eefng c\u00e2n nh\u1eafc v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c, xenogh\u00e9p c\u00f3 kh\u1ea3 n\u0103ng thay \u0111\u1ed5i ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb suy \u0111a c\u01a1 quan v\u00e0 c\u1ee9u s\u1ed1ng v\u00f4 s\u1ed1 ng\u01b0\u1eddi.<\/p>","protected":false},"excerpt":{"rendered":"

C\u1ea5y gh\u00e9p tim l\u1ee3n: Th\u00e0nh c\u00f4ng v\u00e0 Th\u00e1ch th\u1ee9c Xenogh\u00e9p: M\u1ed9t gi\u1ea3i ph\u00e1p \u0111\u1ea7y tri\u1ec3n v\u1ecdng cho t\u00ecnh tr\u1ea1ng suy \u0111a c\u01a1 quan Xenogh\u00e9p, vi\u1ec7c gh\u00e9p c\u00e1c c\u01a1 quan t\u1eeb…<\/p>\n","protected":false},"author":2,"featured_media":24717,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1862],"tags":[358,99,15427,15426,15425],"class_list":["post-11393","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-research","tag-medical-innovation","tag-lifescienceart","tag-organ-failure","tag-pig-heart-transplant","tag-xenotransplantation"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/11393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=11393"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/11393\/revisions"}],"predecessor-version":[{"id":24718,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/11393\/revisions\/24718"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media\/24717"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=11393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=11393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=11393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}