{"id":12658,"date":"2022-05-26T04:53:16","date_gmt":"2022-05-26T04:53:16","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=12658"},"modified":"2022-05-26T04:53:16","modified_gmt":"2022-05-26T04:53:16","slug":"mini-brains-eye-like-features-retinal-disease-research","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/biomedical-research\/mini-brains-eye-like-features-retinal-disease-research\/","title":{"rendered":"N\u00e3o si\u00eau nh\u1ecf c\u00f3 m\u1eaft: B\u01b0\u1edbc ti\u1ebfn v\u01b0\u1ee3t b\u1eadc trong nghi\u00ean c\u1ee9u v\u00f5ng m\u1ea1c"},"content":{"rendered":"<h2 class=\"wp-block-heading\">N\u00e3o si\u00eau nh\u1ecf c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng m\u1eaft: B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong nghi\u00ean c\u1ee9u b\u1ec7nh v\u00f5ng m\u1ea1c<\/h2>\n\n<h2 class=\"wp-block-heading\">Hi\u1ec3u v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1eaft<\/h2>\n\n<p>Hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1ch m\u1eaft ph\u00e1t tri\u1ec3n l\u00e0 r\u1ea5t quan tr\u1ecdng \u0111\u1ed1i v\u1edbi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00ecm c\u00e1ch kh\u00e1m ph\u00e1 nh\u1eefng b\u00ed \u1ea9n c\u1ee7a c\u00e1c b\u1ec7nh v\u00f5ng m\u1ea1c \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u. M\u1ed9t nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng b\u01b0\u1edbc ti\u1ebfn \u0111\u00e1ng k\u1ec3 trong l\u0129nh v\u1ef1c n\u00e0y b\u1eb1ng c\u00e1ch nu\u00f4i c\u1ea5y th\u00e0nh c\u00f4ng n\u00e3o si\u00eau nh\u1ecf v\u1edbi c\u00e1c c\u1ea5u tr\u00fac gi\u1ed1ng m\u1eaft \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 v\u00f5ng m\u1ea1c m\u1eaft. C\u00e1c v\u00f5ng m\u1ea1c m\u1eaft n\u00e0y l\u00e0 ti\u1ec1n th\u00e2n c\u1ee7a v\u00f5ng m\u1ea1c v\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ch\u00fang b\u00ean trong c\u00e1c organoid si\u00eau nh\u1ecf r\u1ea5t gi\u1ed1ng v\u1edbi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c c\u1ea5u tr\u00fac m\u1eaft trong ph\u00f4i ng\u01b0\u1eddi.<\/p>\n\n<h2 class=\"wp-block-heading\">Organoid: T\u00e1i t\u1ea1o c\u00e1c c\u01a1 quan trong ph\u00f2ng th\u00ed nghi\u1ec7m<\/h2>\n\n<p>Organoid l\u00e0 c\u00e1c m\u1eabu nu\u00f4i c\u1ea5y m\u00f4 ba chi\u1ec1u nh\u1ecf m\u00f4 ph\u1ecfng c\u1ea5u tr\u00fac v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a c\u00e1c c\u01a1 quan. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1o ra c\u00e1c organoid nh\u1ecf t\u1eeb t\u1ebf b\u00e0o g\u1ed1c, c\u00f3 kh\u1ea3 n\u0103ng ph\u00e1t tri\u1ec3n th\u00e0nh b\u1ea5t k\u1ef3 t\u1ebf b\u00e0o n\u00e0o trong c\u01a1 th\u1ec3. Nghi\u00ean c\u1ee9u c\u00e1c organoid cho ph\u00e9p c\u00e1c nh\u00e0 khoa h\u1ecdc quan s\u00e1t c\u00e1ch c\u00e1c c\u01a1 quan ph\u00e1t tri\u1ec3n v\u00e0 ph\u1ea3n \u1ee9ng v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nhau.<\/p>\n\n<h2 class=\"wp-block-heading\">N\u00e3o si\u00eau nh\u1ecf nu\u00f4i c\u1ea5y t\u1eeb iPSC<\/h2>\n\n<p>Trong nghi\u00ean c\u1ee9u mang t\u00ednh \u0111\u1ed9t ph\u00e1 n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c \u0111a n\u0103ng c\u1ea3m \u1ee9ng \u1edf ng\u01b0\u1eddi (iPSC) \u0111\u1ec3 nu\u00f4i c\u1ea5y n\u00e3o si\u00eau nh\u1ecf. iPSC l\u00e0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c tr\u01b0\u1edfng th\u00e0nh c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ph\u00f4i ng\u01b0\u1eddi. Tuy nhi\u00ean, kh\u00f4ng gi\u1ed1ng nh\u01b0 c\u00e1c t\u1ebf b\u00e0o g\u1ed1c ph\u00f4i truy\u1ec1n th\u1ed1ng, iPSC \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb c\u00e1c t\u1ebf b\u00e0o c\u01a1 th\u1ec3 ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh, th\u01b0\u1eddng l\u00e0 t\u1eeb da ho\u1eb7c m\u00e1u. Nh\u1eefng t\u1ebf b\u00e0o n\u00e0y sau \u0111\u00f3 \u0111\u01b0\u1ee3c t\u00e1i l\u1eadp tr\u00ecnh v\u1ec1 tr\u1ea1ng th\u00e1i gi\u1ed1ng nh\u01b0 ph\u00f4i, cho ph\u00e9p ch\u00fang ph\u00e1t tri\u1ec3n th\u00e0nh b\u1ea5t k\u1ef3 t\u1ebf b\u00e0o n\u00e0o trong c\u01a1 th\u1ec3.<\/p>\n\n<h2 class=\"wp-block-heading\">Ph\u00e1t tri\u1ec3n v\u00f5ng m\u1ea1c m\u1eaft<\/h2>\n\n<p>C\u00e1c n\u1ed7 l\u1ef1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y t\u1eadp trung v\u00e0o vi\u1ec7c nu\u00f4i c\u1ea5y ri\u00eang c\u00e1c t\u1ebf b\u00e0o v\u00f5ng m\u1ea1c thu\u1ea7n t\u00fay ho\u1eb7c v\u00f5ng m\u1ea1c m\u1eaft. Tuy nhi\u00ean, nghi\u00ean c\u1ee9u n\u00e0y nh\u1eb1m m\u1ee5c \u0111\u00edch t\u1ea1o ra m\u1ed9t h\u1ec7 th\u1ed1ng t\u00edch h\u1ee3p b\u1eb1ng c\u00e1ch nu\u00f4i c\u1ea5y v\u00f5ng m\u1ea1c m\u1eaft nh\u01b0 m\u1ed9t ph\u1ea7n c\u1ee7a n\u00e3o si\u00eau nh\u1ecf. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eeda \u0111\u1ed5i m\u1ed9t k\u1ef9 thu\u1eadt \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 chuy\u1ec3n \u0111\u1ed5i t\u1ebf b\u00e0o g\u1ed1c th\u00e0nh m\u00f4 th\u1ea7n kinh \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee5c ti\u00eau n\u00e0y.<\/p>\n\n<p>Sau khi c\u00e1c t\u1ebf b\u00e0o ph\u00e1t tri\u1ec3n th\u00e0nh n\u00e3o si\u00eau nh\u1ecf, v\u00f5ng m\u1ea1c m\u1eaft xu\u1ea5t hi\u1ec7n trong v\u00f2ng 30 ng\u00e0y v\u00e0 tr\u01b0\u1edfng th\u00e0nh ho\u00e0n to\u00e0n v\u00e0o ng\u00e0y th\u1ee9 50. Th\u1eddi \u0111i\u1ec3m ph\u00e1t tri\u1ec3n n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1eaft \u1edf ph\u00f4i ng\u01b0\u1eddi, cho th\u1ea5y qu\u00e1 tr\u00ecnh n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 nghi\u00ean c\u1ee9u s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1eaft trong t\u1eed cung.<\/p>\n\n<h2 class=\"wp-block-heading\">C\u00e1c c\u1ea5u tr\u00fac ph\u1ee9c t\u1ea1p v\u00e0 nh\u1ea1y s\u00e1ng<\/h2>\n\n<p>\u0110i\u1ec1u \u0111\u00e1ng ch\u00fa \u00fd l\u00e0 v\u00f5ng m\u1ea1c m\u1eaft tr\u00ean n\u00e3o si\u00eau nh\u1ecf bi\u1ec3u hi\u1ec7n \u0111\u1ed9 nh\u1ea1y s\u00e1ng v\u00e0 ph\u00e1t tri\u1ec3n nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o v\u00f5ng m\u1ea1c \u0111\u01b0\u1ee3c k\u1ebft n\u1ed1i v\u1edbi m\u00f4 n\u01a1-ron. M\u1eaft tr\u00ean c\u00e1c organoid th\u1eadm ch\u00ed c\u00f2n c\u00f3 c\u1ea3 th\u1ee7y tinh th\u1ec3 v\u00e0 m\u00f4 gi\u00e1c m\u1ea1c.<\/p>\n\n<h2 class=\"wp-block-heading\">C\u00e1c \u1ee9ng d\u1ee5ng ti\u1ec1m n\u0103ng<\/h2>\n\n<p>S\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u00e3o si\u00eau nh\u1ecf c\u00f3 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m gi\u1ed1ng m\u1eaft c\u00f3 \u00fd ngh\u0129a to l\u1edbn \u0111\u1ed1i v\u1edbi nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh v\u00f5ng m\u1ea1c. C\u00e1c organoid n\u00e0y c\u00f3 th\u1ec3 gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Nghi\u00ean c\u1ee9u s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa n\u00e3o v\u00e0 m\u1eaft trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n ph\u00f4i thai<\/li>\n<li>L\u1eadp m\u00f4 h\u00ecnh c\u00e1c r\u1ed1i lo\u1ea1n v\u00f5ng m\u1ea1c b\u1ea9m sinh<\/li>\n<li>T\u1ea1o ra c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o v\u00f5ng m\u1ea1c \u0111\u1eb7c hi\u1ec7u cho t\u1eebng b\u1ec7nh nh\u00e2n \u0111\u1ec3 th\u1eed nghi\u1ec7m thu\u1ed1c \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a<\/li>\n<li>Ph\u00e1t tri\u1ec3n c\u00e1c li\u1ec7u ph\u00e1p gh\u00e9p cho c\u00e1c b\u1ec7nh v\u00f5ng m\u1ea1c<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">H\u01b0\u1edbng nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai<\/h2>\n\n<p>C\u00e1c nh\u00e0 khoa h\u1ecdc hi\u1ec7n \u0111ang kh\u00e1m ph\u00e1 c\u00e1c c\u00e1ch k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd c\u1ee7a v\u00f5ng m\u1ea1c m\u1eaft \u0111\u1ec3 t\u1ea1o \u0111i\u1ec1u ki\u1ec7n cho c\u00e1c nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n v\u1ec1 c\u00e1c r\u1ed1i lo\u1ea1n v\u00f5ng m\u1ea1c. Nghi\u00ean c\u1ee9u n\u00e0y r\u1ea5t h\u1ee9a h\u1eb9n trong vi\u1ec7c th\u00fac \u0111\u1ea9y s\u1ef1 hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1eaft v\u00e0 m\u1edf \u0111\u01b0\u1eddng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho c\u00e1c b\u1ec7nh v\u00f5ng m\u1ea1c.<\/p>","protected":false},"excerpt":{"rendered":"<p>N\u00e3o si\u00eau nh\u1ecf c\u00f3 c\u1ea5u tr\u00fac gi\u1ed1ng m\u1eaft: B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong nghi\u00ean c\u1ee9u b\u1ec7nh v\u00f5ng m\u1ea1c Hi\u1ec3u v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1eaft Hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1ch m\u1eaft ph\u00e1t tri\u1ec3n&hellip;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3713],"tags":[17083,1867,1579,17085,2112,17084,17086,16118],"class_list":["post-12658","post","type-post","status-publish","format-standard","hentry","category-biomedical-research","tag-retinal-disease","tag-biotechnology","tag-neuroscience","tag-mini-brains","tag-medical-research","tag-organoids","tag-eye-development","tag-stem-cells"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/12658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=12658"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/12658\/revisions"}],"predecessor-version":[{"id":12659,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/12658\/revisions\/12659"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=12658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=12658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=12658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}