{"id":13760,"date":"2024-09-16T00:54:24","date_gmt":"2024-09-16T00:54:24","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=13760"},"modified":"2024-09-16T00:54:24","modified_gmt":"2024-09-16T00:54:24","slug":"aspirin-a-century-of-discoveries","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/medicine\/aspirin-a-century-of-discoveries\/","title":{"rendered":"Aspirin: M\u1ed9t th\u1ebf k\u1ef7 kh\u00e1m ph\u00e1"},"content":{"rendered":"

Aspirin: M\u1ed9t th\u1ebf k\u1ef7 kh\u00e1m ph\u00e1<\/h2>\n\n

Kh\u1edfi \u0111\u1ea7u khi\u00eam t\u1ed1n c\u1ee7a Aspirin<\/h2>\n\n

Trong nhi\u1ec1u th\u1ebf k\u1ef7, con ng\u01b0\u1eddi \u0111\u00e3 d\u1ef1a v\u00e0o c\u00e1c ph\u01b0\u01a1ng thu\u1ed1c t\u1ef1 nhi\u00ean \u0111\u1ec3 gi\u1ea3m \u0111au v\u00e0 ch\u1ed1ng vi\u00eam. M\u1ed9t trong nh\u1eefng ph\u01b0\u01a1ng thu\u1ed1c \u0111\u00f3 l\u00e0 salicin, m\u1ed9t h\u1ee3p ch\u1ea5t c\u00f3 trong v\u1ecf c\u00e2y li\u1ec5u tr\u1eafng. V\u00e0o \u0111\u1ea7u th\u1ebf k\u1ef7 19, c\u00e1c nh\u00e0 h\u00f3a h\u1ecdc \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t d\u1ea1ng salicin c\u00f4 \u0111\u1eb7c h\u01a1n, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 axit salicylic. M\u1eb7c d\u00f9 c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c h\u1ea1 s\u1ed1t, nh\u01b0ng axit salicylic c\u00f3 m\u1ed9t nh\u01b0\u1ee3c \u0111i\u1ec3m l\u1edbn: n\u00f3 c\u00f3 th\u1ec3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y.<\/p>\n\n

S\u1ef1 ra \u0111\u1eddi c\u1ee7a axit acetylsalicylic (Aspirin)<\/h2>\n\n

N\u0103m 1897, m\u1ed9t nh\u00e0 h\u00f3a h\u1ecdc tr\u1ebb tu\u1ed5i t\u00ean l\u00e0 Felix Hoffmann, l\u00e0m vi\u1ec7c cho c\u00f4ng ty Bayer c\u1ee7a \u0110\u1ee9c, \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1. \u00d4ng \u0111\u00e3 kh\u00e1m ph\u00e1 ra m\u1ed9t c\u00e1ch \u0111\u1ec3 bi\u1ebfn \u0111\u1ed5i axit salicylic b\u1eb1ng c\u00e1ch g\u1eafn m\u1ed9t nh\u00f3m acetyl v\u00e0o \u0111\u00f3, t\u1ea1o ra axit acetylsalicylic – lo\u1ea1i aspirin m\u00e0 ch\u00fang ta bi\u1ebft ng\u00e0y nay.<\/p>\n\n

T\u00ednh ch\u1ea5t gi\u1ea3m \u0111au c\u1ee7a Aspirin<\/h2>\n\n

Kh\u1ea3 n\u0103ng gi\u1ea3m \u0111au v\u00e0 h\u1ea1 s\u1ed1t c\u1ee7a Aspirin \u0111\u00e3 nhanh ch\u00f3ng \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn. Bayer \u0111\u00e3 \u0111\u01b0a lo\u1ea1i thu\u1ed1c n\u00e0y ra th\u1ecb tr\u01b0\u1eddng v\u1edbi t\u00ean g\u1ecdi l\u00e0 aspirin, v\u00e0 n\u00f3 nhanh ch\u00f3ng tr\u1edf th\u00e0nh m\u1ed9t m\u1eb7t h\u00e0ng gia d\u1ee5ng thi\u1ebft y\u1ebfu. V\u00e0o nh\u1eefng n\u0103m 1950, m\u1ed9t b\u00e1c s\u0129 t\u00ean l\u00e0 Lawrence Craven \u0111\u00e3 c\u00f3 m\u1ed9t kh\u00e1m ph\u00e1 quan tr\u1ecdng kh\u00e1c: aspirin c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba c\u1ee5c m\u00e1u \u0111\u00f4ng h\u00ecnh th\u00e0nh trong c\u00e1c \u0111\u1ed9ng m\u1ea1ch cung c\u1ea5p m\u00e1u cho tim.<\/p>\n\n

Vai tr\u00f2 c\u1ee7a Aspirin \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe tim m\u1ea1ch<\/h2>\n\n

C\u00e1c nghi\u00ean c\u1ee9u l\u1edbn sau \u0111\u00f3 \u0111\u00e3 x\u00e1c nh\u1eadn nh\u1eefng ph\u00e1t hi\u1ec7n c\u1ee7a Craven. Aspirin \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 \u0111au tim \u0111\u1ea7u ti\u00ean t\u1edbi 44% v\u00e0 nguy c\u01a1 \u0111au tim th\u1ee9 hai t\u1edbi 30%. T\u00ednh ch\u1ea5t ch\u1ed1ng \u0111\u00f4ng m\u00e1u c\u1ee7a Aspirin khi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t lo\u1ea1i thu\u1ed1c c\u00f3 gi\u00e1 tr\u1ecb \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh tim.<\/p>\n\n

Aspirin v\u00e0 ph\u00f2ng ng\u1eeba ung th\u01b0<\/h2>\n\n

Ngo\u00e0i nh\u1eefng l\u1ee3i \u00edch v\u1ec1 tim m\u1ea1ch, aspirin c\u0169ng cho th\u1ea5y nh\u1eefng h\u1ee9a h\u1eb9n trong vi\u1ec7c ng\u0103n ng\u1eeba m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0. Nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng aspirin c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 ung th\u01b0 ru\u1ed9t k\u1ebft t\u1edbi 40%, ung th\u01b0 th\u1ef1c qu\u1ea3n t\u1edbi 80-90% v\u00e0 ung th\u01b0 bu\u1ed3ng tr\u1ee9ng t\u1edbi 25%.<\/p>\n\n

Aspirin v\u00e0 c\u00e1c b\u1ec7nh tho\u00e1i h\u00f3a th\u1ea7n kinh<\/h2>\n\n

Aspirin c\u0169ng c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng b\u1ea3o v\u1ec7 th\u1ea7n kinh. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng n\u00f3 c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a ch\u1ee9ng m\u1ea5t tr\u00ed nh\u1edb v\u00e0 b\u1ec7nh Alzheimer. Tuy nhi\u00ean, c\u1ea7n nhi\u1ec1u nghi\u00ean c\u1ee9u h\u01a1n \u0111\u1ec3 hi\u1ec3u \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 vai tr\u00f2 ti\u1ec1m t\u00e0ng c\u1ee7a aspirin trong \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh n\u00e0y.<\/p>\n\n

T\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 th\u1eadn tr\u1ecdng khi d\u00f9ng Aspirin<\/h2>\n\n

M\u1eb7c d\u00f9 aspirin th\u01b0\u1eddng an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, nh\u01b0ng n\u00f3 c\u00f3 th\u1ec3 g\u00e2y ra m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5, bao g\u1ed3m \u0111au b\u1ee5ng, bu\u1ed3n n\u00f4n v\u00e0 ch\u1ea3y m\u00e1u. Nh\u1eefng ng\u01b0\u1eddi c\u00f3 ti\u1ec1n s\u1eed lo\u00e9t d\u1ea1 d\u00e0y ho\u1eb7c r\u1ed1i lo\u1ea1n ch\u1ea3y m\u00e1u n\u00ean tham kh\u1ea3o \u00fd ki\u1ebfn b\u00e1c s\u0129 tr\u01b0\u1edbc khi d\u00f9ng aspirin.<\/p>\n\n

Aspirin: M\u1ed9t lo\u1ea1i thu\u1ed1c \u0111a n\u0103ng v\u00e0 b\u1ec1n v\u1eefng<\/h2>\n\n

T\u1eeb kh\u1edfi \u0111\u1ea7u khi\u00eam t\u1ed1n l\u00e0 m\u1ed9t ph\u01b0\u01a1ng thu\u1ed1c t\u1ef1 nhi\u00ean cho \u0111\u1ebfn v\u1ecb th\u1ebf hi\u1ec7n t\u1ea1i l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i, aspirin c\u00f3 m\u1ed9t l\u1ecbch s\u1eed phong ph\u00fa v\u00e0 h\u1ea5p d\u1eabn. C\u00e1c \u0111\u1eb7c t\u00ednh gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t v\u00e0 ch\u1ed1ng \u0111\u00f4ng m\u00e1u c\u1ee7a n\u00f3 \u0111\u00e3 bi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t th\u00e0nh ph\u1ea7n ch\u00ednh trong t\u1ee7 thu\u1ed1c gia \u0111\u00ecnh tr\u00ean kh\u1eafp th\u1ebf gi\u1edbi. M\u1eb7c d\u00f9 c\u00e1c nghi\u00ean c\u1ee9u \u0111ang ti\u1ebfp t\u1ee5c ti\u1ebft l\u1ed9 nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m n\u0103ng m\u1edbi, nh\u01b0ng t\u00ednh linh ho\u1ea1t v\u00e0 s\u1ef1 ph\u1ed5 bi\u1ebfn l\u00e2u d\u00e0i c\u1ee7a aspirin ch\u00ednh l\u00e0 minh ch\u1ee9ng cho hi\u1ec7u qu\u1ea3 v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a n\u00f3.<\/p>","protected":false},"excerpt":{"rendered":"

Aspirin: M\u1ed9t th\u1ebf k\u1ef7 kh\u00e1m ph\u00e1 Kh\u1edfi \u0111\u1ea7u khi\u00eam t\u1ed1n c\u1ee7a Aspirin Trong nhi\u1ec1u th\u1ebf k\u1ef7, con ng\u01b0\u1eddi \u0111\u00e3 d\u1ef1a v\u00e0o c\u00e1c ph\u01b0\u01a1ng thu\u1ed1c t\u1ef1 nhi\u00ean \u0111\u1ec3 gi\u1ea3m \u0111au v\u00e0…<\/p>\n","protected":false},"author":2,"featured_media":24351,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359],"tags":[18501,18503,1108,1332,18502],"class_list":["post-13760","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","tag-aspirin","tag-neuroprotection","tag-cancer-prevention","tag-heart-health","tag-pain-relief"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=13760"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13760\/revisions"}],"predecessor-version":[{"id":24352,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13760\/revisions\/24352"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media\/24351"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=13760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=13760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=13760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}