{"id":13774,"date":"2026-09-19T16:40:15","date_gmt":"2026-09-19T16:40:15","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=13774"},"modified":"2026-09-19T16:40:15","modified_gmt":"2026-09-19T16:40:15","slug":"personalized-mrna-vaccine-shows-promise-against-melanoma","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/medicine\/personalized-mrna-vaccine-shows-promise-against-melanoma\/","title":{"rendered":"Vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a cho melanoma gi\u1ea3m 44% nguy c\u01a1 t\u00e1i ph\u00e1t \u2013 B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong \u0111i\u1ec1u tr\u1ecb"},"content":{"rendered":"

Vaccine mRNA C\u00e1 Nh\u00e2n H\u00f3a Cho T\u0103ng Da L\u00e0nh<\/h2>\n\n

B\u1ed1i C\u1ea3nh<\/h2>\n\n

Melanoma l\u00e0 lo\u1ea1i ung th\u01b0 da nguy hi\u1ec3m nh\u1ea5t, chi\u1ebfm ph\u1ea7n l\u1edbn c\u00e1c ca t\u1eed vong do b\u1ec7nh n\u00e0y. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng cho melanoma bao g\u1ed3m ph\u1eabu thu\u1eadt, ho\u00e1 tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb. Tuy nhi\u00ean, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u00e1ng k\u1ec3 v\u00e0 kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o c\u0169ng hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t.<\/p>\n\n

C\u00f4ng Ngh\u1ec7 Vaccine mRNA<\/h2>\n\n

Vaccine mRNA l\u00e0 m\u1ed9t lo\u1ea1i vaccine m\u1edbi \u0111\u00e3 cho th\u1ea5y ti\u1ec1m n\u0103ng trong vi\u1ec7c ph\u00f2ng ng\u1eeba v\u00e0 \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u lo\u1ea1i b\u1ec7nh, bao g\u1ed3m c\u1ea3 ung th\u01b0. Vaccine mRNA ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch \u0111\u01b0a messenger RNA (mRNA) v\u00e0o c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3, sau \u0111\u00f3 h\u01b0\u1edbng d\u1eabn c\u00e1c t\u1ebf b\u00e0o n\u00e0y s\u1ea3n xu\u1ea5t protein k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch.<\/p>\n\n

Vaccine mRNA C\u00e1 Nh\u00e2n H\u00f3a cho Melanoma<\/h2>\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a cho melanoma, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf ri\u00eang cho t\u1eebng b\u1ec7nh nh\u00e2n d\u1ef1a tr\u00ean kh\u1ed1i u c\u1ee7a h\u1ecd. Vaccine \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u \u0111\u01b0\u1ee3c l\u1ea5y ra t\u1eeb b\u1ec7nh nh\u00e2n trong qu\u00e1 tr\u00ecnh ph\u1eabu thu\u1eadt. C\u00e1c t\u1ebf b\u00e0o n\u00e0y sau \u0111\u00f3 \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh c\u00e1c neoantigen \u0111\u1ed9c \u0111\u00e1o hi\u1ec7n di\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a ch\u00fang. Neoantigen l\u00e0 c\u00e1c protein ch\u1ec9 xu\u1ea5t hi\u1ec7n trong t\u1ebf b\u00e0o ung th\u01b0 m\u00e0 kh\u00f4ng c\u00f3 trong t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh.<\/p>\n\n

Vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 d\u1ea1y h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n nh\u1eadn di\u1ec7n v\u00e0 t\u1ea5n c\u00f4ng nh\u1eefng neoantigen n\u00e0y. B\u1eb1ng c\u00e1ch nh\u1eafm m\u1ee5c ti\u00eau nhi\u1ec1u neoantigen, vaccine c\u00f3 th\u1ec3 k\u00edch th\u00edch ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh m\u1ebd v\u00e0 hi\u1ec7u qu\u1ea3 h\u01a1n.<\/p>\n\n

K\u1ebft Qu\u1ea3 Th\u1eed Nghi\u1ec7m Giai \u0110o\u1ea1n 2<\/h2>\n\n

M\u1ed9t th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2 c\u1ee7a vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a cho melanoma \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n g\u1ea7n \u0111\u00e2y, v\u00e0 k\u1ebft qu\u1ea3 \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y t\u1ea1i h\u1ed9i ngh\u1ecb c\u1ee7a Hi\u1ec7p h\u1ed9i Ung th\u01b0 Hoa K\u1ef3 (AACR). Th\u1eed nghi\u1ec7m bao g\u1ed3m 157 b\u1ec7nh nh\u00e2n melanoma c\u00f3 nguy c\u01a1 cao, nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1eaft b\u1ecf kh\u1ed1i u qua ph\u1eabu thu\u1eadt.<\/p>\n\n

C\u00e1c b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c ph\u00e2n ng\u1eabu nhi\u00ean \u0111\u1ec3 nh\u1eadn ho\u1eb7c vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch Keytruda, ho\u1eb7c ch\u1ec9 nh\u1eadn Keytruda. K\u1ebft qu\u1ea3 cho th\u1ea5y s\u1ef1 k\u1ebft h\u1ee3p gi\u1eefa vaccine v\u00e0 Keytruda hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 h\u01a1n trong vi\u1ec7c ng\u0103n ng\u1eeba t\u00e1i ph\u00e1t so v\u1edbi ch\u1ec9 d\u00f9ng Keytruda.<\/p>\n\n

C\u1ee5 th\u1ec3, trong v\u00f2ng hai n\u0103m, ung th\u01b0 \u0111\u00e3 quay tr\u1edf l\u1ea1i \u1edf 40\u202f% b\u1ec7nh nh\u00e2n ch\u1ec9 d\u00f9ng Keytruda. Trong khi \u0111\u00f3, ch\u1ec9 c\u00f3 22\u202f% b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb k\u1ebft h\u1ee3p c\u1ea3 hai ph\u01b0\u01a1ng ph\u00e1p c\u00f3 t\u00e1i ph\u00e1t. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 vi\u1ec7c s\u1eed d\u1ee5ng vaccine \u0111\u00e3 gi\u1ea3m nguy c\u01a1 t\u00e1i ph\u00e1t ho\u1eb7c t\u1eed vong c\u1ee7a b\u1ec7nh nh\u00e2n xu\u1ed1ng 44\u202f% so v\u1edbi ch\u1ec9 d\u00f9ng Keytruda.<\/p>\n\n

\u00dd Ngh\u0129a c\u1ee7a K\u1ebft Qu\u1ea3<\/h2>\n\n

K\u1ebft qu\u1ea3 c\u1ee7a th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 2 r\u1ea5t \u0111\u00e1ng mong \u0111\u1ee3i v\u00e0 g\u1ee3i \u00fd r\u1eb1ng vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 l\u1edbn trong \u0111i\u1ec1u tr\u1ecb melanoma. Vaccine c\u00f3 \u0111\u1ed9 dung n\u1ea1p t\u1ed1t v\u00e0 ti\u1ec1m n\u0103ng c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n m\u1eafc b\u1ec7nh nguy hi\u1ec3m n\u00e0y.<\/p>\n\n

C\u00e1c B\u01b0\u1edbc Ti\u1ebfp Theo<\/h2>\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hi\u1ec7n \u0111ang l\u00ean k\u1ebf ho\u1ea1ch cho m\u1ed9t th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 3 c\u1ee7a vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a cho melanoma. Th\u1eed nghi\u1ec7m n\u00e0y s\u1ebd bao g\u1ed3m s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n l\u1edbn h\u01a1n v\u00e0 s\u1ebd \u0111\u00e1nh gi\u00e1 s\u00e2u h\u01a1n v\u1ec1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a vaccine. N\u1ebfu th\u1eed nghi\u1ec7m giai \u0111o\u1ea1n 3 th\u00e0nh c\u00f4ng, vaccine c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t s\u1eed d\u1ee5ng trong v\u00f2ng ba n\u0103m t\u1edbi.<\/p>\n\n

K\u1ebft Lu\u1eadn<\/h2>\n\n

Vi\u1ec7c ph\u00e1t tri\u1ec3n vaccine mRNA c\u00e1 nh\u00e2n h\u00f3a cho melanoma l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn quan tr\u1ecdng trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh nguy hi\u1ec3m n\u00e0y. Vaccine \u0111\u00e3 cho th\u1ea5y k\u1ebft qu\u1ea3 \u0111\u1ea7y h\u1ee9a h\u1eb9n trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ban \u0111\u1ea7u, v\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hy v\u1ecdng r\u1eb1ng cu\u1ed1i c\u00f9ng n\u00f3 s\u1ebd \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n.<\/p>","protected":false},"excerpt":{"rendered":"

Vaccine mRNA C\u00e1 Nh\u00e2n H\u00f3a Cho T\u0103ng Da L\u00e0nh B\u1ed1i C\u1ea3nh Melanoma l\u00e0 lo\u1ea1i ung th\u01b0 da nguy hi\u1ec3m nh\u1ea5t, chi\u1ebfm ph\u1ea7n l\u1edbn c\u00e1c ca t\u1eed vong do b\u1ec7nh n\u00e0y.…<\/p>\n","protected":false},"author":2,"featured_media":25578,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359],"tags":[18523,18526,3368,18522,18524,5613,18527,18525],"class_list":["post-13774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","tag-cancer-vaccine","tag-clinical-trial","tag-immunotherapy","tag-melanoma","tag-mrna-vaccine","tag-cancer-research","tag-phase-2-trial","tag-personalized-medicine"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=13774"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13774\/revisions"}],"predecessor-version":[{"id":25579,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/13774\/revisions\/25579"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media\/25578"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=13774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=13774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=13774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}