Nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c cho l\u00e0 gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n, nh\u01b0ng nh\u1eefng nghi\u00ean c\u1ee9u m\u1edbi ch\u1ec9 ra r\u1eb1ng \u0111i\u1ec1u n\u00e0y kh\u00f4ng ho\u00e0n to\u00e0n \u0111\u00fang. Khi l\u1edbn l\u00ean v\u00e0 ph\u00e1t tri\u1ec3n, nh\u1eefng c\u1eb7p song sinh n\u00e0y c\u00f3 th\u1ec3 s\u1edf h\u1eefu m\u1ed9t t\u1eadp h\u1ee3p c\u00e1c \u0111\u1ed9t bi\u1ebfn ri\u00eang bi\u1ec7t, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3 v\u1ec1 m\u1eb7t di truy\u1ec1n gi\u1eefa ch\u00fang.<\/p>\n\n
\u0110\u1ed9t bi\u1ebfn soma l\u00e0 nh\u1eefng \u0111\u1ed9t bi\u1ebfn x\u1ea3y ra trong c\u00e1c t\u1ebf b\u00e0o c\u1ee7a c\u01a1 th\u1ec3 sau khi th\u1ee5 thai. Nh\u1eefng \u0111\u1ed9t bi\u1ebfn n\u00e0y c\u00f3 th\u1ec3 ph\u00e1t sinh trong qu\u00e1 tr\u00ecnh ph\u00e2n chia t\u1ebf b\u00e0o ho\u1eb7c do ti\u1ebfp x\u00fac v\u1edbi c\u00e1c y\u1ebfu t\u1ed1 m\u00f4i tr\u01b0\u1eddng nh\u01b0 b\u1ee9c x\u1ea1 ho\u1eb7c h\u00f3a ch\u1ea5t.<\/p>\n\n
M\u1ed9t nghi\u00ean c\u1ee9u do Rui Li t\u1ea1i \u0110\u1ea1i h\u1ecdc McGill th\u1ef1c hi\u1ec7n \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng m\u1ed9t c\u1eb7p song sinh trung b\u00ecnh c\u00f3 359 \u0111\u1ed9t bi\u1ebfn soma trong b\u1ed9 gen c\u1ee7a m\u00ecnh, t\u1ea5t c\u1ea3 \u0111\u1ec1u x\u1ea3y ra trong giai \u0111o\u1ea1n \u0111\u1ea7u ph\u00e1t tri\u1ec3n. Nh\u1eefng \u0111\u1ed9t bi\u1ebfn n\u00e0y c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u lo\u1ea1i gen, bao g\u1ed3m c\u00e1c gen li\u00ean quan \u0111\u1ebfn ngo\u1ea1i h\u00ecnh, kh\u1ea3 n\u0103ng m\u1eafc b\u1ec7nh v\u00e0 h\u00e0nh vi.<\/p>\n\n
Ngo\u00e0i \u0111\u1ed9t bi\u1ebfn soma, nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng c\u0169ng c\u00f3 th\u1ec3 kh\u00e1c nhau v\u1ec1 m\u1eb7t di truy\u1ec1n \u1edf nh\u1eefng kh\u00eda c\u1ea1nh kh\u00e1c. V\u00ed d\u1ee5, m\u1ed9t trong hai \u0111\u1ee9a tr\u1ebb c\u00f3 th\u1ec3 c\u00f3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea3n sao c\u1ee7a m\u1ed9t gen c\u1ee5 th\u1ec3 kh\u00e1c v\u1edbi \u0111\u1ee9a tr\u1ebb c\u00f2n l\u1ea1i. \u0110\u00e2y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 bi\u1ebfn th\u1ec3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea3n sao (CNV).<\/p>\n\n
CNV c\u00f3 th\u1ec3 c\u00f3 t\u00e1c \u0111\u1ed9ng \u0111\u00e1ng k\u1ec3 \u0111\u1ebfn k\u1ebft qu\u1ea3 s\u1ee9c kh\u1ecfe. V\u00ed d\u1ee5, trong m\u1ed9t nghi\u00ean c\u1ee9u c\u1ee7a Carl Bruder t\u1ea1i \u0110\u1ea1i h\u1ecdc Alabama \u1edf Birmingham, m\u1ed9t trong hai \u0111\u1ee9a tr\u1ebb song sinh b\u1ecb thi\u1ebfu m\u1ed9t s\u1ed1 gen tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 c\u1ee5 th\u1ec3, cho th\u1ea5y nguy c\u01a1 m\u1eafc b\u1ec7nh b\u1ea1ch c\u1ea7u, v\u00e0 \u0111\u1ee9a tr\u1ebb n\u00e0y th\u1ef1c s\u1ef1 \u0111\u00e3 m\u1eafc b\u1ec7nh. \u0110\u1ee9a tr\u1ebb song sinh c\u00f2n l\u1ea1i kh\u00f4ng thi\u1ebfu nh\u1eefng gen n\u00e0y v\u00e0 kh\u00f4ng m\u1eafc b\u1ec7nh b\u1ea1ch c\u1ea7u.<\/p>\n\n
Th\u1ef1c t\u1ebf l\u00e0 nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng kh\u00f4ng th\u1ef1c s\u1ef1 gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng \u0111\u1ed1i v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u1eb7p song sinh. C\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u1eb7p song sinh th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tra vai tr\u00f2 c\u1ee7a gen v\u00e0 m\u00f4i tr\u01b0\u1eddng trong c\u00e1c b\u1ec7nh ph\u1ee9c t\u1ea1p nh\u01b0 t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u00e0 t\u1ef1 k\u1ef7.<\/p>\n\n
N\u1ebfu nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng kh\u00f4ng gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n, th\u00ec s\u1ebd kh\u00f3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u1ee7a gen \u0111\u1ebfn nh\u1eefng c\u0103n b\u1ec7nh n\u00e0y. Ngo\u00e0i ra, c\u00f3 th\u1ec3 kh\u00f3 kh\u0103n h\u01a1n khi s\u1eed d\u1ee5ng nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng l\u00e0m nh\u00f3m \u0111\u1ed1i ch\u1ee9ng trong c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 r\u1ee7i ro v\u1ec1 m\u00f4i tr\u01b0\u1eddng.<\/p>\n\n
Ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng kh\u00f4ng gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n nh\u01b0 ch\u00fang ta v\u1eabn ngh\u0129 c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng \u0111\u1ed1i v\u1edbi s\u1ef1 hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 di truy\u1ec1n h\u1ecdc v\u00e0 b\u1ec7nh t\u1eadt. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i xem x\u00e9t nh\u1eefng kh\u00e1c bi\u1ec7t v\u1ec1 m\u1eb7t di truy\u1ec1n n\u00e0y khi di\u1ec5n gi\u1ea3i k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u v\u1ec1 c\u1eb7p song sinh v\u00e0 khi \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh v\u1ec1 vi\u1ec7c ch\u0103m s\u00f3c y t\u1ebf cho nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng.<\/p>\n\n
M\u1ed9t nghi\u00ean c\u1ee9u do Rui Li t\u1ea1i \u0110\u1ea1i h\u1ecdc McGill th\u1ef1c hi\u1ec7n \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng m\u1ed9t c\u1eb7p song sinh trung b\u00ecnh c\u00f3 359 \u0111\u1ed9t bi\u1ebfn soma trong b\u1ed9 gen c\u1ee7a m\u00ecnh, t\u1ea5t c\u1ea3 \u0111\u1ec1u x\u1ea3y ra trong giai \u0111o\u1ea1n \u0111\u1ea7u ph\u00e1t tri\u1ec3n.<\/p>\n\n
Ngo\u00e0i \u0111\u1ed9t bi\u1ebfn soma, nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng c\u0169ng c\u00f3 th\u1ec3 kh\u00e1c nhau v\u1ec1 m\u1eb7t di truy\u1ec1n \u1edf nh\u1eefng kh\u00eda c\u1ea1nh kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0:<\/p>\n\n
C\u00e1c bi\u1ebfn th\u1ec3 di truy\u1ec1n gi\u1eefa nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn k\u1ebft qu\u1ea3 s\u1ee9c kh\u1ecfe c\u1ee7a ch\u00fang theo nhi\u1ec1u c\u00e1ch. V\u00ed d\u1ee5, m\u1ed9t trong hai \u0111\u1ee9a tr\u1ebb c\u00f3 th\u1ec3 d\u1ec5 m\u1eafc m\u1ed9t c\u0103n b\u1ec7nh c\u1ee5 th\u1ec3 h\u01a1n \u0111\u1ee9a tr\u1ebb c\u00f2n l\u1ea1i ho\u1eb7c ch\u00fang c\u00f3 th\u1ec3 ph\u1ea3n \u1ee9ng kh\u00e1c nhau v\u1edbi c\u00f9ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb.<\/p>\n\n
Th\u1ef1c t\u1ebf l\u00e0 nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng kh\u00f4ng th\u1ef1c s\u1ef1 gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t di truy\u1ec1n c\u00f3 nh\u1eefng h\u1ea1n ch\u1ebf \u0111\u1ed1i v\u1edbi vi\u1ec7c s\u1eed d\u1ee5ng ch\u00fang trong c\u00e1c nghi\u00ean c\u1ee9u di truy\u1ec1n. V\u00ed d\u1ee5, c\u00f3 th\u1ec3 kh\u00f3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng c\u1ee7a gen \u0111\u1ebfn nh\u1eefng c\u0103n b\u1ec7nh ph\u1ee9c t\u1ea1p v\u00e0 c\u00f3 th\u1ec3 kh\u00f3 kh\u0103n h\u01a1n khi s\u1eed d\u1ee5ng nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng l\u00e0m nh\u00f3m \u0111\u1ed1i ch\u1ee9ng trong c\u00e1c nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 r\u1ee7i ro v\u1ec1 m\u00f4i tr\u01b0\u1eddng.<\/p>\n\n
Kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng n\u00e0o cho th\u1ea5y nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng c\u00f3 th\u1ec3 tho\u00e1t t\u1ed9i gi\u1ebft ng\u01b0\u1eddi nh\u1edd nh\u1eefng \u0111i\u1ec3m t\u01b0\u01a1ng \u0111\u1ed3ng v\u1ec1 m\u1eb7t di truy\u1ec1n c\u1ee7a ch\u00fang. M\u1eb7c d\u00f9 nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng c\u00f3 th\u1ec3 c\u00f3 nhi\u1ec1u \u0111\u1eb7c \u0111i\u1ec3m v\u1ec1 m\u1eb7t th\u1ec3 ch\u1ea5t v\u00e0 di truy\u1ec1n gi\u1ed1ng nhau, nh\u01b0ng ch\u00fang v\u1eabn l\u00e0 hai c\u00e1 th\u1ec3 ri\u00eang bi\u1ec7t, c\u00f3 nh\u1eefng suy ngh\u0129, c\u1ea3m x\u00fac v\u00e0 \u0111\u1ed9ng l\u1ef1c ri\u00eang bi\u1ec7t.<\/p>","protected":false},"excerpt":{"rendered":"
Nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng: Kh\u00f4ng gi\u1ed1ng h\u1ec7t nhau nh\u01b0 ch\u00fang ta v\u1eabn ngh\u0129 Nh\u1eefng c\u1eb7p song sinh c\u00f9ng tr\u1ee9ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c cho l\u00e0 gi\u1ed1ng h\u1ec7t nhau v\u1ec1 m\u1eb7t…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1628],"tags":[8138,20371,16486,188,20372,20370,20368,20369],"class_list":["post-15274","post","type-post","status-publish","format-standard","hentry","category-genetics","tag-nature-vs-nurture","tag-copy-number-variants","tag-epigenetics","tag-genetics","tag-genetics-and-disease","tag-somatic-mutations","tag-identical-twins","tag-twin-studies"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=15274"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15274\/revisions"}],"predecessor-version":[{"id":15275,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15274\/revisions\/15275"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=15274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=15274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=15274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}