{"id":15567,"date":"2022-12-01T08:40:02","date_gmt":"2022-12-01T08:40:02","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=15567"},"modified":"2022-12-01T08:40:02","modified_gmt":"2022-12-01T08:40:02","slug":"diet-drugs-novel-approach-mosquito-control","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/life-sciences\/diet-drugs-novel-approach-mosquito-control\/","title":{"rendered":"Thu\u1ed1c gi\u1ea3m c\u00e2n: L\u1ed1i tho\u00e1t m\u1edbi cho b\u00e0i to\u00e1n ki\u1ec3m so\u00e1t mu\u1ed7i"},"content":{"rendered":"

Thu\u1ed1c gi\u1ea3m c\u00e2n: M\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi trong vi\u1ec7c ki\u1ec3m so\u00e1t mu\u1ed7i<\/h2>\n\n

Mu\u1ed7i: M\u1ed9t m\u1ed1i phi\u1ec1n to\u00e1i th\u00fac \u0111\u1ea9y b\u1edfi c\u01a1n \u0111\u00f3i<\/h2>\n\n

Mu\u1ed7i th\u01b0\u1eddng b\u1ecb coi l\u00e0 nh\u1eefng lo\u00e0i g\u00e2y h\u1ea1i khi\u1ebfn c\u00e1c ho\u1ea1t \u0111\u1ed9ng ngo\u00e0i tr\u1eddi c\u1ee7a ch\u00fang ta tr\u1edf n\u00ean kh\u00f3 ch\u1ecbu. Tuy nhi\u00ean, h\u00e0nh vi h\u00fat m\u00e1u c\u1ee7a ch\u00fang xu\u1ea5t ph\u00e1t t\u1eeb nhu c\u1ea7u sinh h\u1ecdc: mu\u1ed7i c\u00e1i c\u1ea7n h\u00fat m\u00e1u \u0111\u1ec3 s\u1ea3n xu\u1ea5t tr\u1ee9ng. C\u01a1n \u0111\u00f3i n\u00e0y th\u00fac \u0111\u1ea9y ch\u00fang t\u00ecm ki\u1ebfm con ng\u01b0\u1eddi v\u00e0 \u0111\u1ed9ng v\u1eadt l\u00e0m ngu\u1ed3n th\u1ee9c \u0103n.<\/p>\n\n

Thu\u1ed1c gi\u1ea3m c\u00e2n v\u00e0 vi\u1ec7c ng\u0103n ch\u1eb7n s\u1ef1 th\u00e8m \u0103n c\u1ee7a mu\u1ed7i<\/h2>\n\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 kh\u00e1m ph\u00e1 ra m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi trong vi\u1ec7c ki\u1ec3m so\u00e1t mu\u1ed7i: s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3m c\u00e2n \u0111\u1ec3 ng\u0103n ch\u1eb7n c\u01a1n \u0111\u00f3i c\u1ee7a ch\u00fang. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y, nh\u1eafm v\u00e0o c\u00e1c th\u1ee5 th\u1ec3 neuropeptide Y (NPY), \u0111\u01b0\u1ee3c bi\u1ebft l\u00e0 c\u00f3 t\u00e1c d\u1ee5ng \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 th\u00e8m \u0103n \u1edf ng\u01b0\u1eddi v\u00e0 c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt kh\u00e1c.<\/p>\n\n

Nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o NPYLR7: Ch\u00eca kh\u00f3a \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 th\u00e8m \u0103n<\/h2>\n\n

M\u1ed9t th\u1ee5 th\u1ec3 NPY c\u1ee5 th\u1ec3, NPYLR7, \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 ch\u00eca kh\u00f3a \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 th\u00e8m \u0103n c\u1ee7a mu\u1ed7i. B\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 t\u1ea1o ra nh\u1eefng con mu\u1ed7i kh\u00f4ng th\u1ec3 t\u1ea1o ra NPYLR7. Nh\u1eefng con mu\u1ed7i n\u00e0y kh\u00f4ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi thu\u1ed1c gi\u1ea3m c\u00e2n, \u0111i\u1ec1u n\u00e0y c\u00e0ng kh\u1eb3ng \u0111\u1ecbnh th\u00eam vai tr\u00f2 c\u1ee7a NPYLR7 trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh c\u01a1n \u0111\u00f3i.<\/p>\n\n

H\u1ee3p ch\u1ea5t 18: M\u1ed9t l\u1ef1a ch\u1ecdn thay th\u1ebf \u0111\u1ea7y h\u1ee9a h\u1eb9n cho c\u00e1c lo\u1ea1i thu\u1ed1c gi\u1ea3m c\u00e2n c\u1ee7a con ng\u01b0\u1eddi<\/h2>\n\n

Vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3m c\u00e2n c\u1ee7a con ng\u01b0\u1eddi \u0111\u1ec3 ki\u1ec3m so\u00e1t mu\u1ed7i l\u00e0 kh\u00f4ng th\u1ef1c t\u1ebf do c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 an to\u00e0n v\u00e0 b\u1eb1ng s\u00e1ng ch\u1ebf. Do \u0111\u00f3, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u00e0ng l\u1ecdc h\u01a1n 265.000 h\u1ee3p ch\u1ea5t \u0111\u1ec3 t\u00ecm ra ch\u1ea5t c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t th\u1ee5 th\u1ec3 NPYLR7. H\u1ee3p ch\u1ea5t 18 n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean \u0111\u1ea7y h\u1ee9a h\u1eb9n, c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c \u1ee9c ch\u1ebf h\u00e0nh vi \u0111\u1ed1t ng\u01b0\u1eddi c\u1ee7a mu\u1ed7i sau khi ti\u1ebfp x\u00fac.<\/p>\n\n

\u01afu \u0111i\u1ec3m c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n \u0111\u1ec3 ki\u1ec3m so\u00e1t mu\u1ed7i<\/h2>\n\n

Ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n c\u00f3 m\u1ed9t s\u1ed1 \u01b0u \u0111i\u1ec3m so v\u1edbi c\u00e1c k\u1ef9 thu\u1eadt ki\u1ec3m so\u00e1t mu\u1ed7i kh\u00e1c. Kh\u00f4ng gi\u1ed1ng nh\u01b0 vi\u1ec7c th\u1ea3 nh\u1eefng con mu\u1ed7i \u0111\u1ef1c \u0111\u00e3 \u0111\u01b0\u1ee3c kh\u1eed tr\u00f9ng ho\u1eb7c nh\u1eefng con mu\u1ed7i bi\u1ebfn \u0111\u1ed5i gen, c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng t\u00e1c \u0111\u1ed9ng ti\u00eau c\u1ef1c \u0111\u1ebfn m\u00f4i tr\u01b0\u1eddng, ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n nh\u1eb1m m\u1ee5c \u0111\u00edch h\u1ea1n ch\u1ebf qu\u1ea7n th\u1ec3 mu\u1ed7i m\u00e0 kh\u00f4ng ti\u00eau di\u1ec7t ch\u00fang. C\u00e1ch ti\u1ebfp c\u1eadn n\u00e0y b\u1ea3o v\u1ec7 c\u00e1c h\u1ec7 sinh th\u00e1i \u0111\u1ecba ph\u01b0\u01a1ng v\u00e0 ng\u0103n ng\u1eeba t\u00e1c h\u1ea1i kh\u00f4ng mong mu\u1ed1n \u0111\u1ed1i v\u1edbi c\u00e1c lo\u00e0i kh\u00e1c.<\/p>\n\n

H\u1ea1n ch\u1ebf v\u00e0 tri\u1ec3n v\u1ecdng trong t\u01b0\u01a1ng lai<\/h2>\n\n

M\u1eb7c d\u00f9 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n \u0111\u00e3 cho th\u1ea5y tri\u1ec3n v\u1ecdng, nh\u01b0ng \u0111i\u1ec1u quan tr\u1ecdng l\u00e0 ph\u1ea3i nh\u1eadn ra nh\u1eefng h\u1ea1n ch\u1ebf c\u1ee7a n\u00f3. Kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ph\u00e1p ki\u1ec3m so\u00e1t mu\u1ed7i n\u00e0o l\u00e0 ho\u00e0n h\u1ea3o v\u00e0 ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n c\u0169ng kh\u00f4ng ph\u1ea3i l\u00e0 ngo\u1ea1i l\u1ec7. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u h\u00ecnh dung vi\u1ec7c s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y k\u1ebft h\u1ee3p v\u1edbi c\u00e1c chi\u1ebfn l\u01b0\u1ee3c kh\u00e1c, ch\u1eb3ng h\u1ea1n nh\u01b0 thu\u1ed1c tr\u1eeb s\u00e2u ho\u1eb7c mu\u1ed7i bi\u1ebfn \u0111\u1ed5i gen, \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 t\u1ed1i \u01b0u.<\/p>\n\n

H\u1ee3p ch\u1ea5t 18: M\u1ed9t c\u00f4ng c\u1ee5 ti\u1ec1m n\u0103ng trong vi\u1ec7c qu\u1ea3n l\u00fd t\u1ed5ng h\u1ee3p mu\u1ed7i<\/h2>\n\n

H\u1ee3p ch\u1ea5t 18, \u1ee9ng c\u1eed vi\u00ean \u0111\u1ea7y h\u1ee9a h\u1eb9n nh\u1ea5t \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong nghi\u00ean c\u1ee9u, c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh m\u1ed9t c\u00f4ng c\u1ee5 c\u00f3 gi\u00e1 tr\u1ecb trong vi\u1ec7c qu\u1ea3n l\u00fd t\u1ed5ng h\u1ee3p mu\u1ed7i. B\u1eb1ng c\u00e1ch ph\u00e1 v\u1ee1 h\u00e0nh vi ki\u1ebfm \u0103n c\u1ee7a mu\u1ed7i, h\u1ee3p ch\u1ea5t n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m s\u1ef1 l\u00e2y truy\u1ec1n b\u1ec7nh, c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng v\u00e0 t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng t\u1eadn h\u01b0\u1edfng kh\u00f4ng gian ngo\u00e0i tr\u1eddi c\u1ee7a ch\u00fang ta.<\/p>\n\n

Nghi\u00ean c\u1ee9u \u0111ang di\u1ec5n ra v\u00e0 nh\u1eefng \u1ee9ng d\u1ee5ng trong t\u01b0\u01a1ng lai<\/h2>\n\n

C\u1ea7n c\u00f3 th\u00eam nghi\u00ean c\u1ee9u \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh m\u1ee9c \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a h\u1ee3p ch\u1ea5t 18 trong \u0111i\u1ec1u ki\u1ec7n th\u1ef1c t\u1ebf. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng \u0111ang kh\u00e1m ph\u00e1 kh\u1ea3 n\u0103ng s\u1eed d\u1ee5ng c\u00f9ng m\u1ed9t lo\u1ea1i h\u00f3a ch\u1ea5t \u0111\u1ec3 ki\u1ec3m so\u00e1t c\u00e1c lo\u1ea1i c\u00f4n tr\u00f9ng kh\u00e1c h\u00fat m\u00e1u ng\u01b0\u1eddi, ch\u1eb3ng h\u1ea1n nh\u01b0 ve. B\u1eb1ng c\u00e1ch ti\u1ebfp t\u1ee5c \u0111\u1ed5i m\u1edbi v\u00e0 c\u1ea3i ti\u1ebfn ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y, ch\u00fang ta c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n c\u00e1c chi\u1ebfn l\u01b0\u1ee3c ki\u1ec3m so\u00e1t mu\u1ed7i hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 th\u00e2n thi\u1ec7n v\u1edbi m\u00f4i tr\u01b0\u1eddng h\u01a1n.<\/p>\n\n

K\u1ebft lu\u1eadn<\/h2>\n\n

Ph\u01b0\u01a1ng ph\u00e1p d\u00f9ng thu\u1ed1c gi\u1ea3m c\u00e2n \u0111\u1ea1i di\u1ec7n cho m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n \u0111\u1ec3 ki\u1ec3m so\u00e1t mu\u1ed7i. B\u1eb1ng c\u00e1ch nh\u1eafm v\u00e0o th\u1ee5 th\u1ec3 NPYLR7, h\u1ee3p ch\u1ea5t 18 c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ng\u0103n ch\u1eb7n c\u01a1n \u0111\u00f3i v\u00e0 h\u00e0nh vi \u0111\u1ed1t ng\u01b0\u1eddi c\u1ee7a mu\u1ed7i. M\u1eb7c d\u00f9 c\u1ea7n c\u00f3 th\u00eam nghi\u00ean c\u1ee9u tr\u01b0\u1edbc khi ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c tri\u1ec3n khai r\u1ed9ng r\u00e3i, nh\u01b0ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng tr\u1edf th\u00e0nh m\u1ed9t c\u00f4ng c\u1ee5 quan tr\u1ecdng trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng c\u00e1c b\u1ec7nh do mu\u1ed7i truy\u1ec1n v\u00e0 c\u1ea3i thi\u1ec7n s\u1ee9c kh\u1ecfe c\u1ed9ng \u0111\u1ed3ng tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.<\/p>","protected":false},"excerpt":{"rendered":"

Thu\u1ed1c gi\u1ea3m c\u00e2n: M\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi trong vi\u1ec7c ki\u1ec3m so\u00e1t mu\u1ed7i Mu\u1ed7i: M\u1ed9t m\u1ed1i phi\u1ec1n to\u00e1i th\u00fac \u0111\u1ea9y b\u1edfi c\u01a1n \u0111\u00f3i Mu\u1ed7i th\u01b0\u1eddng b\u1ecb coi l\u00e0 nh\u1eefng lo\u00e0i…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[762],"tags":[20732,20734,20733,233,20731],"class_list":["post-15567","post","type-post","status-publish","format-standard","hentry","category-life-sciences","tag-appetite-suppression","tag-compound-18","tag-npy-receptor","tag-mosquito-control","tag-diet-drugs"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=15567"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15567\/revisions"}],"predecessor-version":[{"id":15568,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/15567\/revisions\/15568"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=15567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=15567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=15567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}