{"id":16149,"date":"2024-04-12T13:18:36","date_gmt":"2024-04-12T13:18:36","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=16149"},"modified":"2024-04-12T13:18:36","modified_gmt":"2024-04-12T13:18:36","slug":"animal-methuselahs-secrets-extending-lifespan","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/biology\/animal-methuselahs-secrets-extending-lifespan\/","title":{"rendered":"T\u1ea1i sao m\u1ed9t s\u1ed1 lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng th\u1ecd \u0111\u1ebfn v\u1eady: H\u00e9 l\u1ed9 b\u00ed m\u1eadt di truy\u1ec1n c\u1ee7a s\u1ef1 tr\u01b0\u1eddng th\u1ecd"},"content":{"rendered":"<h2 class=\"wp-block-heading\">T\u1ea1i sao m\u1ed9t s\u1ed1 lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u \u0111\u1ebfn v\u1eady: H\u00e9 l\u1ed9 b\u00ed m\u1eadt di truy\u1ec1n c\u1ee7a s\u1ef1 tr\u01b0\u1eddng th\u1ecd<\/h2>\n\n<h2 class=\"wp-block-heading\">\u0110i\u1ec1u g\u00ec khi\u1ebfn m\u1ed9t s\u1ed1 lo\u00e0i \u0111\u1ed9ng v\u1eadt c\u00f3 tu\u1ed5i th\u1ecd cao b\u1ea5t th\u01b0\u1eddng?<\/h2>\n\n<p>Nh\u1eefng lo\u00e0i \u0111\u1ed9ng v\u1eadt nh\u01b0 d\u01a1i, c\u00e1 voi v\u00e0 chu\u1ed9t ch\u0169i tr\u1ee5i l\u00f4ng c\u00f3 tu\u1ed5i th\u1ecd v\u01b0\u1ee3t xa c\u00e1c lo\u00e0i sinh v\u1eadt kh\u00e1c. C\u00e1c nh\u00e0 khoa h\u1ecdc r\u1ea5t mu\u1ed1n kh\u00e1m ph\u00e1 nh\u1eefng b\u00ed m\u1eadt \u0111\u1eb1ng sau s\u1ef1 tr\u01b0\u1eddng th\u1ecd c\u1ee7a ch\u00fang v\u1edbi hy v\u1ecdng k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd c\u1ee7a ch\u00ednh ch\u00fang ta.<\/p>\n\n<h2 class=\"wp-block-heading\">Nh\u1eefng m\u00e1nh kh\u00f3e di truy\u1ec1n v\u00e0 sinh h\u00f3a gi\u00fap k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd<\/h2>\n\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00ecm hi\u1ec3u c\u00e1c c\u01a1 ch\u1ebf di truy\u1ec1n v\u00e0 sinh h\u00f3a gi\u00fap c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u tr\u00ec ho\u00e3n qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a. H\u1ecd \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng lo\u00e0i \u0111\u1ed9ng v\u1eadt n\u00e0y \u0111\u00e3 ti\u1ebfn h\u00f3a nh\u1eefng m\u00e1nh kh\u00f3e \u0111\u1ed9c \u0111\u00e1o, ch\u1eb3ng h\u1ea1n nh\u01b0:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>T\u00edch t\u1ee5 ch\u1eadm h\u01a1n c\u00e1c t\u1ed5n th\u01b0\u01a1ng ph\u00e2n t\u1eed<\/li>\n<li>L\u1eafp r\u00e1p protein ch\u00ednh x\u00e1c h\u01a1n<\/li>\n<li>C\u00e1c con \u0111\u01b0\u1eddng s\u1eeda ch\u1eefa DNA hi\u1ec7u qu\u1ea3 h\u01a1n<\/li>\n<li>H\u1ec7 th\u1ed1ng b\u1ea3o d\u01b0\u1ee1ng t\u1ebf b\u00e0o m\u1ea1nh m\u1ebd h\u01a1n<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Di truy\u1ec1n h\u1ecdc bi\u1ec3u sinh v\u00e0 l\u00e3o h\u00f3a<\/h2>\n\n<p>Di truy\u1ec1n h\u1ecdc bi\u1ec3u sinh, li\u00ean quan \u0111\u1ebfn c\u00e1c s\u1eeda \u0111\u1ed5i h\u00f3a h\u1ecdc \u0111\u1ed1i v\u1edbi DNA, c\u0169ng \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a. Ng\u01b0\u1eddi ta th\u1ea5y r\u1eb1ng c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u bi\u1ec3u sinh \u1ed5n \u0111\u1ecbnh h\u01a1n, gi\u00fap duy tr\u00ec ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen tr\u1ebb trung.<\/p>\n\n<h2 class=\"wp-block-heading\">B\u1ea3n sao gen: M\u1ed9t c\u00e1i nh\u00ecn \u0111\u1ed9ng v\u1ec1 s\u1ef1 bi\u1ec3u hi\u1ec7n gen<\/h2>\n\n<p>B\u1ea3n sao gen, gi\u00fap ph\u00e2n t\u00edch RNA th\u00f4ng tin, cung c\u1ea5p m\u1ed9t c\u00e1i nh\u00ecn \u0111\u1ed9ng v\u1ec1 s\u1ef1 bi\u1ec3u hi\u1ec7n gen. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng nh\u1eefng con d\u01a1i s\u1ed1ng l\u00e2u c\u00f3 h\u1ec7 th\u1ed1ng b\u1ea3o d\u01b0\u1ee1ng m\u1ea1nh m\u1ebd h\u01a1n khi ch\u00fang gi\u00e0 \u0111i, s\u1ea3n sinh ra nhi\u1ec1u ph\u00e2n t\u1eed li\u00ean quan \u0111\u1ebfn s\u1eeda ch\u1eefa h\u01a1n.<\/p>\n\n<h2 class=\"wp-block-heading\">Nh\u1eefng con \u0111\u01b0\u1eddng kh\u00e1c nhau \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c tu\u1ed5i th\u1ecd<\/h2>\n\n<p>\u0110i\u1ec1u th\u00fa v\u1ecb l\u00e0 c\u00e1c lo\u00e0i kh\u00e1c nhau c\u00f3 th\u1ec3 \u0111i theo nh\u1eefng con \u0111\u01b0\u1eddng kh\u00e1c nhau \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c tu\u1ed5i th\u1ecd. V\u00ed d\u1ee5:<\/p>\n\n<ul class=\"wp-block-list\">\n<li>Voi d\u1ef1a v\u00e0o nhi\u1ec1u b\u1ea3n sao c\u1ee7a c\u00e1c gen \u1ee9c ch\u1ebf kh\u1ed1i u.<\/li>\n<li>Chu\u1ed9t ch\u0169i tr\u1ee5i l\u00f4ng c\u00f3 m\u1ed9t ph\u00e2n t\u1eed b\u1ea5t th\u01b0\u1eddng gi\u00fap ch\u00fang ch\u1ed1ng l\u1ea1i ung th\u01b0.<\/li>\n<li>C\u00e1 voi \u0111\u1ea7u b\u00f2 c\u00f3 c\u01a1 ch\u1ebf s\u1eeda ch\u1eefa DNA n\u00e2ng cao.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Ch\u00fang ta c\u00f3 th\u1ec3 h\u1ecdc h\u1ecfi t\u1eeb nh\u1eefng \u0111\u1ed9ng v\u1eadt Methuselah kh\u00f4ng?<\/h2>\n\n<p>S\u1ef1 \u0111a d\u1ea1ng c\u1ee7a c\u00e1c chi\u1ebfn l\u01b0\u1ee3c l\u00e3o h\u00f3a \u1edf \u0111\u1ed9ng v\u1eadt mang l\u1ea1i nh\u1eefng hi\u1ec3u bi\u1ebft gi\u00e1 tr\u1ecb cho nghi\u00ean c\u1ee9u v\u1ec1 l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi. B\u1eb1ng c\u00e1ch nghi\u00ean c\u1ee9u nh\u1eefng con Methuselah n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc hy v\u1ecdng c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u00e1c gen v\u00e0 con \u0111\u01b0\u1eddng ch\u00ednh c\u00f3 kh\u1ea3 n\u0103ng nh\u1eafm m\u1ee5c ti\u00eau \u0111\u1ec3 k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd c\u1ee7a ch\u00ednh ch\u00fang ta.<\/p>\n\n<h2 class=\"wp-block-heading\">Nh\u1eefng \u0111i\u1ec3m kh\u00e1c bi\u1ec7t ch\u00ednh gi\u1eefa \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u v\u00e0 \u0111\u1ed9ng v\u1eadt s\u1ed1ng th\u1ecd<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>Ph\u00e2n b\u1ed5 n\u0103ng l\u01b0\u1ee3ng:<\/strong> \u0110\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u \u0111\u1ea7u t\u01b0 nhi\u1ec1u h\u01a1n v\u00e0o vi\u1ec7c b\u1ea3o d\u01b0\u1ee1ng t\u1ebf b\u00e0o v\u00ec ch\u00fang c\u00f3 nhi\u1ec1u kh\u1ea3 n\u0103ng h\u01b0\u1edfng l\u1ee3i t\u1eeb \u0111i\u1ec1u \u0111\u00f3 h\u01a1n.<\/li>\n<li><strong>Nguy c\u01a1 b\u1ecb s\u0103n m\u1ed3i:<\/strong> C\u00e1c lo\u00e0i c\u00f3 nguy c\u01a1 b\u1ecb s\u0103n m\u1ed3i th\u1ea5p h\u01a1n c\u00f3 xu h\u01b0\u1edbng s\u1ed1ng l\u00e2u h\u01a1n.<\/li>\n<li><strong>S\u1eeda ch\u1eefa DNA:<\/strong> \u0110\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u c\u00f3 c\u00e1c con \u0111\u01b0\u1eddng s\u1eeda ch\u1eefa DNA hi\u1ec7u qu\u1ea3 h\u01a1n \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 t\u00edch t\u1ee5 c\u1ee7a c\u00e1c t\u1ed5n th\u01b0\u01a1ng.<\/li>\n<li><strong>B\u1ea3o d\u01b0\u1ee1ng t\u1ebf b\u00e0o:<\/strong> Nh\u1eefng lo\u00e0i \u0111\u1ed9ng v\u1eadt n\u00e0y c\u00f3 h\u1ec7 th\u1ed1ng m\u1ea1nh m\u1ebd h\u01a1n \u0111\u1ec3 g\u1ea5p protein, ho\u1ea1t \u0111\u1ed9ng c\u1ee7a proteasome v\u00e0 gi\u1ea3i \u0111\u1ed9c.<\/li>\n<li><strong>\u1ed4n \u0111\u1ecbnh bi\u1ec3u sinh:<\/strong> \u0110\u1ed9ng v\u1eadt c\u00f3 v\u00fa s\u1ed1ng l\u00e2u c\u00f3 c\u00e1c d\u1ea5u hi\u1ec7u bi\u1ec3u sinh \u1ed5n \u0111\u1ecbnh h\u01a1n, gi\u00fap duy tr\u00ec ho\u1ea1t \u0111\u1ed9ng c\u1ee7a gen tr\u1ebb trung.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">Ph\u00e2n t\u00edch b\u1ea3n sao gen d\u00e0i h\u1ea1n<\/h2>\n\n<p>Ph\u00e2n t\u00edch b\u1ea3n sao gen d\u00e0i h\u1ea1n \u1edf d\u01a1i \u0111\u00e3 ti\u1ebft l\u1ed9 r\u1eb1ng ch\u00fang t\u0103ng c\u01b0\u1eddng h\u1ec7 th\u1ed1ng b\u1ea3o d\u01b0\u1ee1ng c\u1ee7a m\u00ecnh khi ch\u00fang gi\u00e0 \u0111i, kh\u00f4ng gi\u1ed1ng nh\u01b0 c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa kh\u00e1c. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y nh\u1eefng c\u01a1 ch\u1ebf \u0111\u1ed9c \u0111\u00e1o gi\u00fap k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd \u1edf d\u01a1i.<\/p>\n\n<h2 class=\"wp-block-heading\">L\u1eddi h\u1ee9a h\u1eb9n c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u l\u00e3o h\u00f3a so s\u00e1nh<\/h2>\n\n<p>Nghi\u00ean c\u1ee9u s\u1ef1 \u0111a d\u1ea1ng c\u1ee7a c\u00e1c chi\u1ebfn l\u01b0\u1ee3c l\u00e3o h\u00f3a \u1edf \u0111\u1ed9ng v\u1eadt c\u00f3 th\u1ec3 gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc x\u00e1c \u0111\u1ecbnh nh\u1eefng \u0111i\u1ec3m chung v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn m\u1edbi cho nghi\u00ean c\u1ee9u l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi. B\u1eb1ng c\u00e1ch hi\u1ec3u \u0111\u01b0\u1ee3c nh\u1eefng m\u00e1nh kh\u00f3e \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng b\u1edfi c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u, m\u1ed9t ng\u00e0y n\u00e0o \u0111\u00f3 ch\u00fang ta c\u00f3 th\u1ec3 k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd c\u1ee7a ch\u00ednh m\u00ecnh v\u00e0 s\u1ed1ng kh\u1ecfe m\u1ea1nh, l\u00e2u h\u01a1n.<\/p>","protected":false},"excerpt":{"rendered":"<p>T\u1ea1i sao m\u1ed9t s\u1ed1 lo\u00e0i \u0111\u1ed9ng v\u1eadt s\u1ed1ng l\u00e2u \u0111\u1ebfn v\u1eady: H\u00e9 l\u1ed9 b\u00ed m\u1eadt di truy\u1ec1n c\u1ee7a s\u1ef1 tr\u01b0\u1eddng th\u1ecd \u0110i\u1ec1u g\u00ec khi\u1ebfn m\u1ed9t s\u1ed1 lo\u00e0i \u0111\u1ed9ng v\u1eadt c\u00f3&hellip;<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[288],"tags":[16486,188,501,21428,21426,21427,6518],"class_list":["post-16149","post","type-post","status-publish","format-standard","hentry","category-biology","tag-epigenetics","tag-genetics","tag-aging","tag-longevity-research","tag-transcriptomics","tag-comparative-aging","tag-animal-longevity"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/16149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=16149"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/16149\/revisions"}],"predecessor-version":[{"id":16150,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/16149\/revisions\/16150"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=16149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=16149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=16149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}