{"id":17300,"date":"2021-05-14T00:22:09","date_gmt":"2021-05-14T00:22:09","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=17300"},"modified":"2021-05-14T00:22:09","modified_gmt":"2021-05-14T00:22:09","slug":"dna-based-attack-against-cancer-shows-promise","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/biotechnology\/dna-based-attack-against-cancer-shows-promise\/","title":{"rendered":"Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh \u0111\u1ed9t ph\u00e1 trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ef1a tr\u00ean DNA cho k\u1ebft qu\u1ea3 \u0111\u1ea7y h\u1ee9a h\u1eb9n"},"content":{"rendered":"

Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh \u0111\u1ed9t ph\u00e1 trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ef1a tr\u00ean DNA cho k\u1ebft qu\u1ea3 \u0111\u1ea7y h\u1ee9a h\u1eb9n<\/h2>\n\n

M\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng c\u1ee7a li\u1ec7u ph\u00e1p gen<\/h2>\n\n

M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb mang t\u00ednh \u0111\u1ed9t ph\u00e1 \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi t\u00ean g\u1ecdi li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean chimeric (li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR) \u0111\u00e3 n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i b\u1ec7nh ung th\u01b0. Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh c\u00e1ch t\u00e2n n\u00e0y bao g\u1ed3m vi\u1ec7c bi\u1ebfn \u0111\u1ed5i gen c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00ednh b\u1ec7nh nh\u00e2n \u0111\u1ec3 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n\n

H\u00e0nh tr\u00ecnh c\u1ee7a m\u1ed9t b\u1ec7nh nh\u00e2n<\/h2>\n\n

Dimas Padilla, m\u1ed9t ng\u01b0\u1eddi s\u1ed1ng s\u00f3t sau c\u0103n b\u1ec7nh u lympho kh\u00f4ng Hodgkin, \u0111\u00e3 \u0111\u1ed1i m\u1eb7t v\u1edbi ti\u00ean l\u01b0\u1ee3ng m\u1edd m\u1ecbt sau khi c\u0103n b\u1ec7nh ung th\u01b0 c\u1ee7a \u00f4ng t\u00e1i ph\u00e1t l\u1ea7n th\u1ee9 ba. Tuy nhi\u00ean, \u00f4ng \u0111\u00e3 t\u00ecm th\u1ea5y hy v\u1ecdng nh\u1edd li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR. Sau khi c\u00e1c t\u1ebf b\u00e0o T c\u1ee7a \u00f4ng \u0111\u01b0\u1ee3c thu th\u1eadp, c\u00e1c k\u1ef9 thu\u1eadt vi\u00ean \u0111\u00e3 \u0111\u01b0a m\u1ed9t gen m\u1edbi v\u00e0o c\u00e1c t\u1ebf b\u00e0o n\u00e0y, cho ph\u00e9p c\u00e1c t\u1ebf b\u00e0o s\u1ea3n xu\u1ea5t c\u00e1c th\u1ee5 th\u1ec3 b\u1ec1 m\u1eb7t m\u1edbi c\u00f3 kh\u1ea3 n\u0103ng t\u00ecm ki\u1ebfm v\u00e0 b\u00e1m v\u00e0o c\u00e1c protein \u0111\u1eb7c hi\u1ec7u tr\u00ean c\u00e1c t\u1ebf b\u00e0o u lympho c\u1ee7a \u00f4ng.<\/p>\n\n

Nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng kinh ng\u1ea1c<\/h2>\n\n

Ch\u1ec9 trong v\u00f2ng v\u00e0i tu\u1ea7n sau khi nh\u1eadn \u0111\u01b0\u1ee3c c\u00e1c t\u1ebf b\u00e0o T \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i, kh\u1ed1i u \u1edf c\u1ed5 c\u1ee7a Padilla \u0111\u00e3 teo nh\u1ecf \u0111\u00e1ng k\u1ec3. M\u1ed9t n\u0103m sau, \u00f4ng v\u1eabn kh\u00f4ng c\u00f2n b\u1ecb ung th\u01b0 v\u00e0 \u0103n m\u1eebng s\u1ee9c kh\u1ecfe m\u1edbi c\u1ee7a m\u00ecnh c\u00f9ng gia \u0111\u00ecnh. Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng m\u00e0 Padilla tham gia \u0111\u00e3 cho th\u1ea5y m\u1ed9t th\u00e0nh c\u00f4ng \u0111\u00e1ng kinh ng\u1ea1c, v\u1edbi kho\u1ea3ng m\u1ed9t n\u1eeda s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u1ea1t \u0111\u01b0\u1ee3c m\u1ee9c thuy\u00ean gi\u1ea3m ho\u00e0n to\u00e0n. T\u1ef7 l\u1ec7 th\u00e0nh c\u00f4ng n\u00e0y cao h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng.<\/p>\n\n

S\u1ef1 ch\u1ea5p thu\u1eadn c\u1ee7a FDA v\u00e0 \u00fd ngh\u0129a<\/h2>\n\n

C\u01a1 quan Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 c\u00f4ng nh\u1eadn ti\u1ec1m n\u0103ng c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR v\u00e0 \u0111\u00e3 ch\u1ea5p thu\u1eadn m\u1ed9t phi\u00ean b\u1ea3n c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u00f3 t\u00ean l\u00e0 Yescarta cho m\u1ed9t s\u1ed1 lo\u1ea1i u lympho t\u1ebf b\u00e0o B. \u0110\u00e2y ch\u1ec9 m\u1edbi l\u00e0 li\u1ec7u ph\u00e1p gen th\u1ee9 hai \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/p>\n\n

C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng<\/h2>\n\n

Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 c\u00e1c t\u1ebf b\u00e0o T c\u1ee7a b\u1ec7nh nh\u00e2n bi\u1ec3u hi\u1ec7n m\u1ed9t th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean chimeric (CAR). Th\u1ee5 th\u1ec3 n\u00e0y \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 nh\u1eadn di\u1ec7n v\u00e0 li\u00ean k\u1ebft v\u1edbi m\u1ed9t m\u1ee5c ti\u00eau protein \u0111\u1eb7c hi\u1ec7u tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. Khi \u0111\u00e3 li\u00ean k\u1ebft, c\u00e1c t\u1ebf b\u00e0o T s\u1ebd \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t v\u00e0 ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n\n

R\u1ee7i ro v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5<\/h2>\n\n

M\u1eb7c d\u00f9 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR \u0111\u00e3 cho th\u1ea5y nhi\u1ec1u h\u1ee9a h\u1eb9n, nh\u01b0ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y v\u1eabn c\u00f3 m\u1ed9t s\u1ed1 r\u1ee7i ro v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5. Hi\u1ec7n t\u1ea1i, ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y ch\u1ec9 kh\u1ea3 d\u1ee5ng cho nh\u1eefng b\u1ec7nh nh\u00e2n \u0111\u00e3 tr\u1ea3i qua \u00edt nh\u1ea5t hai ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0ng kh\u00f4ng th\u00e0nh c\u00f4ng. Mi\u1ec5n d\u1ecbch tr\u1ecb li\u1ec7u, bao g\u1ed3m c\u1ea3 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR, c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m nh\u01b0 \u0111\u1ed9c t\u00ednh th\u1ea7n kinh v\u00e0 h\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng cytokine (CRS). CRS l\u00e0 m\u1ed9t t\u00ecnh tr\u1ea1ng \u0111e d\u1ecda t\u00ednh m\u1ea1ng c\u00f3 th\u1ec3 x\u1ea3y ra khi c\u00e1c cytokine \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng b\u1edfi c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u ho\u1ea1t \u0111\u1ed9ng, d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng vi\u00eam.<\/p>\n\n

C\u00e2n nh\u1eafc gi\u1eefa r\u1ee7i ro v\u00e0 l\u1ee3i \u00edch<\/h2>\n\n

B\u1ea5t ch\u1ea5p nh\u1eefng r\u1ee7i ro ti\u1ec1m \u1ea9n, l\u1ee3i \u00edch c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR c\u00f3 th\u1ec3 v\u01b0\u1ee3t tr\u1ed9i h\u01a1n nh\u1eefng kh\u00f3 ch\u1ecbu m\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n ung th\u01b0 giai \u0111o\u1ea1n cu\u1ed1i v\u00e0 c\u00f3 l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb h\u1ea1n ch\u1ebf ph\u1ea3i \u0111\u1ed1i m\u1eb7t. Padilla \u0111\u00e3 tr\u1ea3i qua c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 s\u1ed1t v\u00e0 m\u1ea5t tr\u00ed nh\u1edb t\u1ea1m th\u1eddi, nh\u01b0ng cu\u1ed1i c\u00f9ng \u00f4ng \u0111\u00e3 h\u1ed3i ph\u1ee5c v\u00e0 tr\u1edf l\u1ea1i tr\u1ea1ng th\u00e1i s\u1ee9c kh\u1ecfe b\u00ecnh th\u01b0\u1eddng.<\/p>\n\n

Hy v\u1ecdng cho t\u01b0\u01a1ng lai<\/h2>\n\n

Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR c\u00f3 kh\u1ea3 n\u0103ng c\u00e1ch m\u1ea1ng h\u00f3a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y mang \u0111\u1ebfn hy v\u1ecdng m\u1edbi cho nh\u1eefng b\u1ec7nh nh\u00e2n m\u1eafc c\u00e1c b\u1ec7nh ung th\u01b0 tr\u01b0\u1edbc \u0111\u00e2y kh\u00f4ng th\u1ec3 ch\u1eefa kh\u1ecfi. Tuy nhi\u00ean, c\u1ea7n ph\u1ea3i ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u \u0111\u1ec3 c\u1ea3i thi\u1ec7n hi\u1ec7u qu\u1ea3 v\u00e0 t\u00ednh an to\u00e0n c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y. C\u00e1c c\u00e2n nh\u1eafc v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c c\u0169ng c\u1ea7n \u0111\u01b0\u1ee3c t\u00ednh \u0111\u1ebfn khi li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng r\u1ed9ng r\u00e3i h\u01a1n.<\/p>\n\n

L\u1ee3i \u00edch v\u00e0 th\u00e1ch th\u1ee9c l\u00e2u d\u00e0i<\/h2>\n\n

C\u00e1c l\u1ee3i \u00edch v\u00e0 th\u00e1ch th\u1ee9c l\u00e2u d\u00e0i c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR v\u1eabn \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang t\u00ecm c\u00e1ch \u0111\u1ec3 t\u0103ng hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 b\u1ec1n c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb. H\u1ecd c\u0169ng \u0111ang kh\u00e1m ph\u00e1 c\u00e1c c\u00e1ch \u0111\u1ec3 gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 c\u1ea3i thi\u1ec7n qu\u00e1 tr\u00ecnh h\u1ed3i ph\u1ee5c c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n\n

\u0110i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a<\/h2>\n\n

Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR \u0111\u1ea1i di\u1ec7n cho m\u1ed9t b\u01b0\u1edbc ti\u1ebfn \u0111\u00e1ng k\u1ec3 h\u01b0\u1edbng t\u1edbi ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a. B\u1eb1ng c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb cho ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 c\u1ee5 th\u1ec3 c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n, c\u00e1c b\u00e1c s\u0129 c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 c\u00f3 m\u1ee5c ti\u00eau h\u01a1n. C\u00e1c nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh nh\u1eb1m m\u1ee5c \u0111\u00edch m\u1edf r\u1ed9ng c\u00e1c \u1ee9ng d\u1ee5ng c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR cho nhi\u1ec1u lo\u1ea1i ung th\u01b0 h\u01a1n.<\/p>","protected":false},"excerpt":{"rendered":"

Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn mang t\u00ednh \u0111\u1ed9t ph\u00e1 trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 d\u1ef1a tr\u00ean DNA cho k\u1ebft qu\u1ea3 \u0111\u1ea7y h\u1ee9a h\u1eb9n M\u1ed9t c\u1ed9t m\u1ed1c quan tr\u1ecdng c\u1ee7a li\u1ec7u ph\u00e1p…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1763],"tags":[3369,358,3368,15186,22778],"class_list":["post-17300","post","type-post","status-publish","format-standard","hentry","category-biotechnology","tag-cancer-treatment","tag-medical-innovation","tag-immunotherapy","tag-gene-therapy","tag-car-t-cell-therapy"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/17300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=17300"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/17300\/revisions"}],"predecessor-version":[{"id":17301,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/17300\/revisions\/17301"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=17300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=17300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=17300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}