{"id":2383,"date":"2024-10-22T23:39:49","date_gmt":"2024-10-22T23:39:49","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=2383"},"modified":"2024-10-22T23:39:49","modified_gmt":"2024-10-22T23:39:49","slug":"phage-therapy-for-diabetic-foot-ulcers","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/biotechnology\/phage-therapy-for-diabetic-foot-ulcers\/","title":{"rendered":"Virus trong ph\u00e2n \u0111\u1ed9ng v\u1eadt: Hy v\u1ecdng m\u1edbi \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do ti\u1ec3u \u0111\u01b0\u1eddng"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Virus t\u00ecm th\u1ea5y trong ph\u00e2n \u0111\u1ed9ng v\u1eadt c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng<\/h2>\n\n<h2 class=\"wp-block-heading\">Vi khu\u1ea9n th\u1ef1c khu\u1ea9n: V\u0169 kh\u00ed c\u1ee7a t\u1ef1 nhi\u00ean ch\u1ed1ng l\u1ea1i vi khu\u1ea9n kh\u00e1ng thu\u1ed1c<\/h2>\n\n<p>Lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng l\u00e0 m\u1ed9t bi\u1ebfn ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn vi\u1ec7c ph\u1ea3i c\u1eaft c\u1ee5t chi. Kh\u00e1ng thu\u1ed1c \u0111\u00e3 khi\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb nh\u1eefng b\u1ec7nh nhi\u1ec5m tr\u00f9ng n\u00e0y ng\u00e0y c\u00e0ng kh\u00f3 kh\u0103n. Tuy nhi\u00ean, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang kh\u00e1m ph\u00e1 ra m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n: li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n.<\/p>\n\n<p>Li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n s\u1eed d\u1ee5ng c\u00e1c vi khu\u1ea9n th\u1ef1c khu\u1ea9n, l\u00e0 c\u00e1c lo\u1ea1i virus c\u00f3 th\u1ec3 l\u00e2y nhi\u1ec5m v\u00e0 ti\u00eau di\u1ec7t c\u00e1c lo\u1ea1i vi khu\u1ea9n c\u1ee5 th\u1ec3. Kh\u00f4ng gi\u1ed1ng nh\u01b0 thu\u1ed1c kh\u00e1ng sinh c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i cho vi khu\u1ea9n c\u00f3 l\u1ee3i, th\u1ef1c khu\u1ea9n ch\u1ec9 nh\u1eafm v\u00e0o nh\u1eefng vi khu\u1ea9n ch\u1ee7 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh c\u1ee7a ch\u00fang. Ph\u01b0\u01a1ng ph\u00e1p nh\u1eafm m\u1ee5c ti\u00eau n\u00e0y l\u00e0m gi\u1ea3m nguy c\u01a1 ph\u00e1t tri\u1ec3n t\u00ecnh tr\u1ea1ng kh\u00e1ng thu\u1ed1c kh\u00e1ng sinh.<\/p>\n\n<h2 class=\"wp-block-heading\">Ph\u00e2n \u0111\u1ed9ng v\u1eadt: M\u1ed9t ngu\u1ed3n \u0111a d\u1ea1ng th\u1ef1c khu\u1ea9n kh\u00f4ng ng\u1edd t\u1edbi<\/h2>\n\n<p>Trong m\u1ed9t b\u01b0\u1edbc ngo\u1eb7t \u0111\u1ed9c \u0111\u00e1o, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng ph\u00e2n \u0111\u1ed9ng v\u1eadt ch\u1ee9a r\u1ea5t nhi\u1ec1u th\u1ef1c khu\u1ea9n c\u00f3 c\u00e1c \u1ee9ng d\u1ee5ng \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng. B\u1eb1ng c\u00e1ch ph\u00e2n l\u1eadp c\u00e1c th\u1ef1c khu\u1ea9n t\u1eeb ph\u00e2n c\u1ee7a c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt trong s\u1edf th\u00fa, c\u00e1c nh\u00e0 khoa h\u1ecdc mu\u1ed1n x\u00e1c \u0111\u1ecbnh c\u00e1c lo\u1ea1i th\u1ef1c khu\u1ea9n c\u00f3 hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ch\u1ed1ng l\u1ea1i vi khu\u1ea9n g\u00e2y lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng.<\/p>\n\n<p>S\u1ef1 \u0111a d\u1ea1ng sinh h\u1ecdc \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ph\u00e2n \u0111\u1ed9ng v\u1eadt h\u1ee9a h\u1eb9n s\u1ebd kh\u00e1m ph\u00e1 ra nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb m\u1edbi cho c\u00e1c b\u1ec7nh truy\u1ec1n nhi\u1ec5m. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin r\u1eb1ng \u0111\u00e2y ch\u1ec9 l\u00e0 ph\u1ea7n n\u1ed5i c\u1ee7a t\u1ea3ng b\u0103ng tr\u00f4i v\u1ec1 c\u00e1c \u1ee9ng d\u1ee5ng y t\u1ebf ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c lo\u1ea1i th\u1ef1c khu\u1ea9n c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb \u0111\u1ed9ng v\u1eadt.<\/p>\n\n<h2 class=\"wp-block-heading\">Ph\u00e2n l\u1eadp v\u00e0 m\u00f4 t\u1ea3 \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a th\u1ef1c khu\u1ea9n<\/h2>\n\n<p>\u0110\u1ec3 ph\u00e2n l\u1eadp th\u1ef1c khu\u1ea9n t\u1eeb ph\u00e2n \u0111\u1ed9ng v\u1eadt, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tr\u1ed9n m\u1eabu v\u1edbi n\u01b0\u1edbc v\u00e0 l\u1ecdc l\u1ea5y th\u1ef1c khu\u1ea9n. Sau \u0111\u00f3, h\u1ecd th\u1eed nghi\u1ec7m t\u1eebng lo\u1ea1i th\u1ef1c khu\u1ea9n \u0111\u1ed1i v\u1edbi nhi\u1ec1u lo\u1ea1i vi khu\u1ea9n kh\u00e1c nhau \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ph\u1ea1m vi v\u1eadt ch\u1ee7 c\u1ee7a ch\u00fang. Ngo\u00e0i ra, h\u1ecd c\u00f2n nghi\u00ean c\u1ee9u DNA c\u1ee7a th\u1ef1c khu\u1ea9n v\u00e0 ch\u1ee5p \u1ea3nh hi\u1ec3n vi \u0111\u1ec3 so s\u00e1nh v\u1edbi c\u00e1c lo\u1ea1i th\u1ef1c khu\u1ea9n \u0111\u00e3 bi\u1ebft.<\/p>\n\n<h2 class=\"wp-block-heading\">Li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n cho lo\u00e9t b\u00e0n ch\u00e2n c\u1ee7a b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng: M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi \u0111\u1ea7y h\u1ee9a h\u1eb9n<\/h2>\n\n<p>Lo\u00e9t b\u00e0n ch\u00e2n c\u1ee7a b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng ph\u00e1t tri\u1ec3n do b\u1ec7nh th\u1ea7n kinh, m\u1ed9t bi\u1ebfn ch\u1ee9ng c\u1ee7a b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng g\u00e2y m\u1ea5t c\u1ea3m gi\u00e1c \u1edf b\u00e0n ch\u00e2n. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn c\u00e1c v\u1ebft th\u01b0\u01a1ng kh\u00f4ng \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n b\u1ecb nhi\u1ec5m tr\u00f9ng. N\u1ebfu thu\u1ed1c kh\u00e1ng sinh kh\u00f4ng di\u1ec7t \u0111\u01b0\u1ee3c vi khu\u1ea9n, c\u00f3 th\u1ec3 ph\u1ea3i c\u1eaft c\u1ee5t chi.<\/p>\n\n<p>Li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n cung c\u1ea5p m\u1ed9t gi\u1ea3i ph\u00e1p ti\u1ec1m n\u0103ng cho c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng kh\u00e1ng thu\u1ed1c n\u00e0y. B\u1eb1ng c\u00e1ch \u00e1p d\u1ee5ng c\u00e1c lo\u1ea1i th\u1ef1c khu\u1ea9n \u0111\u00e3 thanh l\u1ecdc v\u00e0o v\u1ebft th\u01b0\u01a1ng, c\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf vi khu\u1ea9n v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh l\u00e0nh b\u1ec7nh. Ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn n\u00e0y c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m \u0111\u00e1ng k\u1ec3 s\u1ed1 ca ph\u1ea3i c\u1eaft c\u1ee5t chi v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng cho b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng.<\/p>\n\n<h2 class=\"wp-block-heading\">Con \u0111\u01b0\u1eddng ph\u00eda tr\u01b0\u1edbc: Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u00e0 h\u01a1n th\u1ebf n\u1eefa<\/h2>\n\n<p>Nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c lo\u1ea1i th\u1ef1c khu\u1ea9n c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb ph\u00e2n \u0111\u1ed9ng v\u1eadt d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng v\u1eabn \u0111ang trong giai \u0111o\u1ea1n \u0111\u1ea7u. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p n\u00e0y.<\/p>\n\n<p>N\u1ebfu th\u00e0nh c\u00f4ng, li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n c\u00f3 th\u1ec3 c\u00e1ch m\u1ea1ng h\u00f3a vi\u1ec7c \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, cung c\u1ea5p m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p thay th\u1ebf r\u1ea5t c\u1ea7n thi\u1ebft cho thu\u1ed1c kh\u00e1ng sinh v\u00e0 gi\u1ea3m g\u00e1nh n\u1eb7ng ph\u1ea3i c\u1eaft c\u1ee5t chi.<\/p>\n\n<h2 class=\"wp-block-heading\">C\u00e1c l\u1ee3i \u00edch b\u1ed5 sung c\u1ee7a li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n<\/h2>\n\n<p>Ngo\u00e0i ti\u1ec1m n\u0103ng \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n c\u00f2n mang l\u1ea1i m\u1ed9t s\u1ed1 l\u1ee3i \u00edch b\u1ed5 sung:<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>Li\u1ec7u ph\u00e1p nh\u1eafm m\u1ee5c ti\u00eau:<\/strong> Th\u1ef1c khu\u1ea9n ch\u1ec9 nh\u1eafm v\u00e0o c\u00e1c lo\u1ea1i vi khu\u1ea9n c\u1ee5 th\u1ec3, l\u00e0m gi\u1ea3m nguy c\u01a1 g\u00e2y h\u1ea1i cho c\u00e1c vi khu\u1ea9n c\u00f3 l\u1ee3i.<\/li>\n<li><strong>Gi\u1ea3m t\u00ecnh tr\u1ea1ng kh\u00e1ng thu\u1ed1c kh\u00e1ng sinh:<\/strong> Th\u1ef1c khu\u1ea9n c\u00f3 th\u1ec3 gi\u00fap ch\u1ed1ng l\u1ea1i v\u1ea5n \u0111\u1ec1 ng\u00e0y c\u00e0ng gia t\u0103ng c\u1ee7a vi khu\u1ea9n kh\u00e1ng thu\u1ed1c.<\/li>\n<li><strong>Ti\u1ec1m n\u0103ng ph\u00e1t tri\u1ec3n thu\u1ed1c m\u1edbi:<\/strong> Nghi\u00ean c\u1ee9u v\u1ec1 th\u1ef1c khu\u1ea9n c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng khu\u1ea9n m\u1edbi.<\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\">K\u1ebft lu\u1eadn<\/h2>\n\n<p>Ph\u00e1t hi\u1ec7n ra th\u1ef1c khu\u1ea9n trong ph\u00e2n \u0111\u1ed9ng v\u1eadt \u0111\u00e3 m\u1edf ra nh\u1eefng h\u01b0\u1edbng \u0111i m\u1edbi \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng kh\u00e1ng thu\u1ed1c, bao g\u1ed3m c\u1ea3 lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng. V\u1edbi s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a nghi\u00ean c\u1ee9u, li\u1ec7u ph\u00e1p th\u1ef1c khu\u1ea9n h\u1ee9a h\u1eb9n s\u1ebd c\u1ea3i thi\u1ec7n cu\u1ed9c s\u1ed1ng c\u1ee7a v\u00f4 s\u1ed1 b\u1ec7nh nh\u00e2n.<\/p>","protected":false},"excerpt":{"rendered":"<p>Virus t\u00ecm th\u1ea5y trong ph\u00e2n \u0111\u1ed9ng v\u1eadt c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb lo\u00e9t b\u00e0n ch\u00e2n do b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng Vi khu\u1ea9n th\u1ef1c khu\u1ea9n: V\u0169 kh\u00ed c\u1ee7a t\u1ef1 nhi\u00ean ch\u1ed1ng l\u1ea1i&hellip;<\/p>\n","protected":false},"author":2,"featured_media":24675,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1763],"tags":[1438,4871,761,4873,1703,99,4872],"class_list":["post-2383","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-antibiotic-resistance","tag-bacteriophages","tag-infectious-diseases","tag-diabetic-foot-ulcers","tag-microbiome","tag-lifescienceart","tag-phage-therapy"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=2383"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2383\/revisions"}],"predecessor-version":[{"id":24676,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2383\/revisions\/24676"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media\/24675"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=2383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=2383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=2383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}