{"id":2517,"date":"2023-07-09T15:54:29","date_gmt":"2023-07-09T15:54:29","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=2517"},"modified":"2023-07-09T15:54:29","modified_gmt":"2023-07-09T15:54:29","slug":"gut-microbiome-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/neuroscience\/gut-microbiome-alzheimers-disease\/","title":{"rendered":"H\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh Alzheimer: m\u1ed1i li\u00ean h\u1ec7 ch\u1eb7t ch\u1ebd v\u00e0 nh\u1eefng h\u1ee9a h\u1eb9n \u0111i\u1ec1u tr\u1ecb"},"content":{"rendered":"

H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh Alzheimer<\/h2>\n\n

B\u1ec7nh Alzheimer l\u00e0 m\u1ed9t ch\u1ee9ng r\u1ed1i lo\u1ea1n th\u1ea7n kinh tho\u00e1i h\u00f3a t\u00e0n kh\u1ed1c, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf gi\u1edbi. M\u1eb7c d\u00f9 nguy\u00ean nh\u00e2n ch\u00ednh x\u00e1c c\u1ee7a b\u1ec7nh Alzheimer v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5, nh\u01b0ng nghi\u00ean c\u1ee9u ch\u1ec9 ra r\u1eb1ng h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/p>\n\n

H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t l\u00e0 g\u00ec?<\/h3>\n\n

H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t l\u00e0 m\u1ed9t qu\u1ea7n th\u1ec3 kh\u1ed5ng l\u1ed3 g\u1ed3m h\u00e0ng ngh\u00ecn t\u1ef7 vi khu\u1ea9n, vi-r\u00fat v\u00e0 n\u1ea5m s\u1ed1ng trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u1ee7a con ng\u01b0\u1eddi. Nh\u1eefng vi khu\u1ea9n n\u00e0y \u0111\u00f3ng m\u1ed9t vai tr\u00f2 quan tr\u1ecdng trong nhi\u1ec1u ch\u1ee9c n\u0103ng c\u1ee7a c\u01a1 th\u1ec3, bao g\u1ed3m ti\u00eau h\u00f3a, h\u1ea5p th\u1ee5 ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 \u0111i\u1ec1u h\u00f2a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch.<\/p>\n\n

H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh Alzheimer<\/h3>\n\n

C\u00e1c nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 li\u00ean quan ch\u1eb7t ch\u1ebd \u0111\u1ebfn b\u1ec7nh Alzheimer. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh Alzheimer c\u00f3 h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t kh\u00e1c v\u1edbi nh\u1eefng ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh. Nh\u1eefng kh\u00e1c bi\u1ec7t n\u00e0y c\u00f3 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/p>\n\n

Vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Alzheimer nh\u01b0 th\u1ebf n\u00e0o<\/h3>\n\n

M\u1ed9t c\u00e1ch m\u00e0 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn b\u1ec7nh Alzheimer l\u00e0 th\u00f4ng qua t\u00ecnh tr\u1ea1ng vi\u00eam. Khi h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t m\u1ea5t c\u00e2n b\u1eb1ng, n\u00f3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng vi\u00eam m\u1ea1n t\u00ednh tr\u00ean to\u00e0n c\u01a1 th\u1ec3, bao g\u1ed3m c\u1ea3 n\u00e3o. T\u00ecnh tr\u1ea1ng vi\u00eam n\u00e0y c\u00f3 th\u1ec3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng c\u00e1c t\u1ebf b\u00e0o n\u00e3o v\u00e0 g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 ph\u00e1t tri\u1ec3n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Alzheimer, ch\u1eb3ng h\u1ea1n nh\u01b0 m\u1ea5t tr\u00ed nh\u1edb v\u00e0 suy gi\u1ea3m nh\u1eadn th\u1ee9c.<\/p>\n\n

M\u1ed9t c\u00e1ch kh\u00e1c m\u00e0 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn b\u1ec7nh Alzheimer l\u00e0 b\u1eb1ng c\u00e1ch thay \u0111\u1ed5i ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o microglia, m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 trong n\u00e3o. T\u1ebf b\u00e0o microglia c\u00f3 tr\u00e1ch nhi\u1ec7m lo\u1ea1i b\u1ecf c\u00e1c ch\u1ea5t c\u00f3 h\u1ea1i v\u00e0 b\u1ea3o v\u1ec7 n\u00e3o kh\u1ecfi nhi\u1ec5m tr\u00f9ng. Tuy nhi\u00ean, trong b\u1ec7nh Alzheimer, t\u1ebf b\u00e0o microglia tr\u1edf n\u00ean ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c v\u00e0 gi\u1ea3i ph\u00f3ng c\u00e1c ch\u1ea5t h\u00f3a h\u1ecdc g\u00e2y vi\u00eam c\u00f3 th\u1ec3 l\u00e0m t\u1ed5n th\u01b0\u01a1ng c\u00e1c t\u1ebf b\u00e0o n\u00e3o. Vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 k\u00edch ho\u1ea1t ho\u1eb7c duy tr\u00ec t\u00ecnh tr\u1ea1ng ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ee9c c\u1ee7a t\u1ebf b\u00e0o microglia n\u00e0y, g\u00f3p ph\u1ea7n v\u00e0o s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh Alzheimer.<\/p>\n\n

S\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 gi\u1edbi trong h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh Alzheimer<\/h3>\n\n

\u0110i\u1ec1u th\u00fa v\u1ecb l\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng t\u00e1c \u0111\u1ed9ng c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ed1i v\u1edbi b\u1ec7nh Alzheimer c\u00f3 th\u1ec3 kh\u00e1c nhau gi\u1eefa nam v\u00e0 n\u1eef. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng nh\u1eefng con chu\u1ed9t \u0111\u1ef1c m\u1eafc b\u1ec7nh Alzheimer bi\u1ec3u hi\u1ec7n nh\u1eefng thay \u0111\u1ed5i trong h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o microglia, \u0111i\u1ec1u n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf nh\u1eefng con chu\u1ed9t c\u00e1i. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 ri\u00eang bi\u1ec7t theo gi\u1edbi trong s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh Alzheimer.<\/p>\n\n

Nh\u1eefng \u1ea3nh h\u01b0\u1edfng ti\u1ec1m t\u00e0ng \u0111\u1ebfn \u0111i\u1ec1u tr\u1ecb<\/h3>\n\n

Nh\u1eefng ph\u00e1t hi\u1ec7n li\u00ean k\u1ebft h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u1edbi b\u1ec7nh Alzheimer c\u00f3 \u00fd ngh\u0129a quan tr\u1ecdng \u0111\u1ed1i v\u1edbi c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng. B\u1eb1ng c\u00e1ch hi\u1ec3u c\u00e1ch vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Alzheimer, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hy v\u1ecdng s\u1ebd ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi nh\u1eafm v\u00e0o h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ec3 ng\u0103n ng\u1eeba ho\u1eb7c l\u00e0m ch\u1eadm s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/p>\n\n

M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng l\u00e0 s\u1eed d\u1ee5ng men vi sinh, m\u1ed9t lo\u1ea1i vi sinh v\u1eadt s\u1ed1ng c\u00f3 l\u1ee3i cho h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t. Men vi sinh \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m gi\u1ea3m vi\u00eam, \u0111i\u1ec1u ch\u1ec9nh ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o microglia v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ee9c n\u0103ng nh\u1eadn th\u1ee9c \u1edf c\u00e1c m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt c\u1ee7a b\u1ec7nh Alzheimer.<\/p>\n\n

M\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u1ec1m n\u0103ng kh\u00e1c l\u00e0 s\u1eed d\u1ee5ng thu\u1ed1c kh\u00e1ng sinh \u0111\u1ec3 thay \u0111\u1ed5i h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t. M\u1eb7c d\u00f9 kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng thu\u1ed1c kh\u00e1ng sinh trong th\u1eddi gian d\u00e0i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Alzheimer, nh\u01b0ng vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u1ea1n b\u1eb1ng thu\u1ed1c kh\u00e1ng sinh c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang nghi\u00ean c\u1ee9u vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh c\u1ee5 th\u1ec3 ho\u1eb7c k\u1ebft h\u1ee3p c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1ng sinh \u0111\u1ec3 nh\u1eafm v\u00e0o c\u00e1c vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t c\u00f3 h\u1ea1i v\u00e0 c\u1ea3i thi\u1ec7n c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a b\u1ec7nh Alzheimer.<\/p>\n\n

H\u01b0\u1edbng \u0111i trong t\u01b0\u01a1ng lai<\/h3>\n\n

C\u1ea7n c\u00f3 th\u00eam nghi\u00ean c\u1ee9u \u0111\u1ec3 hi\u1ec3u \u0111\u1ea7y \u0111\u1ee7 vai tr\u00f2 c\u1ee7a h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t trong b\u1ec7nh Alzheimer v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 d\u1ef1a tr\u00ean ki\u1ebfn th\u1ee9c n\u00e0y. C\u00e1c nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai s\u1ebd t\u1eadp trung v\u00e0o vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t c\u1ee5 th\u1ec3 g\u00f3p ph\u1ea7n v\u00e0o b\u1ec7nh Alzheimer, hi\u1ec3u r\u00f5 c\u00e1c c\u01a1 ch\u1ebf m\u00e0 vi khu\u1ea9n \u0111\u01b0\u1eddng ru\u1ed9t \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn n\u00e3o v\u00e0 ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c c\u00e1 nh\u00e2n h\u00f3a nh\u1eafm v\u00e0o h\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t \u0111\u1ec3 ng\u0103n ng\u1eeba ho\u1eb7c l\u00e0m ch\u1eadm s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh Alzheimer.<\/p>","protected":false},"excerpt":{"rendered":"

H\u1ec7 vi sinh \u0111\u01b0\u1eddng ru\u1ed9t v\u00e0 b\u1ec7nh Alzheimer B\u1ec7nh Alzheimer l\u00e0 m\u1ed9t ch\u1ee9ng r\u1ed1i lo\u1ea1n th\u1ea7n kinh tho\u00e1i h\u00f3a t\u00e0n kh\u1ed1c, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn h\u00e0ng tri\u1ec7u ng\u01b0\u1eddi tr\u00ean to\u00e0n th\u1ebf…<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[411],"tags":[20997,5590,23179,19381,23180,4283,19807],"class_list":["post-2517","post","type-post","status-publish","format-standard","hentry","category-neuroscience","tag-alzheimers-disease","tag-gut-microbiome","tag-microglia","tag-probiotics","tag-neurodegenerative-disorders","tag-antibiotics","tag-inflammation"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2517","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=2517"}],"version-history":[{"count":1,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2517\/revisions"}],"predecessor-version":[{"id":17654,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2517\/revisions\/17654"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=2517"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=2517"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=2517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}