{"id":2744,"date":"2024-09-07T05:10:51","date_gmt":"2024-09-07T05:10:51","guid":{"rendered":"https:\/\/www.lifescienceart.com\/?p=2744"},"modified":"2024-09-07T05:10:51","modified_gmt":"2024-09-07T05:10:51","slug":"artificial-blood-breakthrough-hemerythrin-safety-concerns","status":"publish","type":"post","link":"https:\/\/www.lifescienceart.com\/vi\/science\/biotechnology\/artificial-blood-breakthrough-hemerythrin-safety-concerns\/","title":{"rendered":"M\u00e1u nh\u00e2n t\u1ea1o: B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 y h\u1ecdc trong t\u01b0\u01a1ng lai"},"content":{"rendered":"

M\u00e1u nh\u00e2n t\u1ea1o: B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 y h\u1ecdc trong t\u01b0\u01a1ng lai<\/h2>\n\n

Ph\u00e1t tri\u1ec3n m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

Trong nhi\u1ec1u th\u1ebf k\u1ef7, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm c\u00e1ch t\u1ea1o ra m\u1ed9t lo\u1ea1i m\u00e1u nh\u00e2n t\u1ea1o an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, c\u00f3 th\u1ec3 c\u1ee9u s\u1ed1ng ng\u01b0\u1eddi trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u1ea5p c\u1ee9u y t\u1ebf v\u00e0 gi\u1ea3i quy\u1ebft nh\u1eefng th\u00e1ch th\u1ee9c c\u1ee7a vi\u1ec7c truy\u1ec1n m\u00e1u. Hemoglobin, m\u1ed9t lo\u1ea1i protein ch\u1ecbu tr\u00e1ch nhi\u1ec7m v\u1eadn chuy\u1ec3n oxy trong c\u00e1c t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u, l\u00e0 tr\u1ecdng t\u00e2m ch\u00ednh c\u1ee7a nh\u1eefng n\u1ed7 l\u1ef1c n\u00e0y. Tuy nhi\u00ean, hemoglobin r\u1ea5t d\u1ec5 v\u1ee1 v\u00e0 c\u00f3 th\u1ec3 b\u1ecb ph\u00e2n h\u1ee7y d\u1ec5 d\u00e0ng khi kh\u00f4ng c\u00f3 m\u00f4i tr\u01b0\u1eddng b\u1ea3o v\u1ec7 c\u1ee7a c\u00e1c t\u1ebf b\u00e0o m\u00e1u.<\/p>\n\n

M\u1ed1i quan ng\u1ea1i v\u1ec1 an to\u00e0n trong nghi\u00ean c\u1ee9u m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

M\u1eb7c d\u00f9 c\u00f3 nh\u1eefng k\u1ebft qu\u1ea3 ban \u0111\u1ea7u \u0111\u1ea7y h\u1ee9a h\u1eb9n, c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 c\u00e1c ch\u1ea5t thay th\u1ebf m\u00e1u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hemoglobin \u0111\u00e3 g\u1eb7p ph\u1ea3i nhi\u1ec1u tr\u1edf ng\u1ea1i do nh\u1eefng lo ng\u1ea1i v\u1ec1 \u0111\u1ed9 an to\u00e0n. HemAssist c\u1ee7a Baxter Healthcare Corporation, \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m v\u00e0o nh\u1eefng n\u0103m 1990, \u0111\u00e3 l\u00e0m gia t\u0103ng t\u1ef7 l\u1ec7 t\u1eed vong \u1edf b\u1ec7nh nh\u00e2n. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, PolyHeme c\u1ee7a Northfield Laboratories c\u0169ng c\u00f3 li\u00ean quan \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ea5n th\u01b0\u01a1ng.<\/p>\n\n

Ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng c\u1ee7a m\u00e1u nh\u00e2n t\u1ea1o trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u1ea5p c\u1ee9u y t\u1ebf<\/h2>\n\n

M\u00e1u nh\u00e2n t\u1ea1o c\u00f3 kh\u1ea3 n\u0103ng c\u00e1ch m\u1ea1ng h\u00f3a ch\u0103m s\u00f3c y t\u1ebf trong nh\u1eefng t\u00ecnh hu\u1ed1ng kh\u00f4ng c\u00f3 m\u00e1u t\u1ef1 nhi\u00ean ho\u1eb7c m\u00e1u t\u1ef1 nhi\u00ean kh\u00f4ng an to\u00e0n. N\u00f3 c\u00f3 th\u1ec3 gi\u00fap lo\u1ea1i b\u1ecf nhu c\u1ea7u truy\u1ec1n m\u00e1u trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p kh\u1ea9n c\u1ea5p, gi\u1ea3m nguy c\u01a1 nhi\u1ec5m tr\u00f9ng v\u00e0 ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng, \u0111\u1ed3ng th\u1eddi cung c\u1ea5p ngu\u1ed3n cung c\u1ea5p m\u00e1u s\u1eb5n c\u00f3 \u0111\u1ec3 s\u1eed d\u1ee5ng tr\u00ean chi\u1ebfn tr\u01b0\u1eddng ho\u1eb7c nh\u1eefng v\u00f9ng xa x\u00f4i.<\/p>\n\n

\u1ee8ng d\u1ee5ng c\u1ee7a Hemerythrin l\u00e0m ch\u1ea5t v\u1eadn chuy\u1ec3n oxy<\/h2>\n\n

Nh\u00e0 khoa h\u1ecdc ng\u01b0\u1eddi Romania Radu Silaghi-Dumitrescu \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i m\u00e1u nh\u00e2n t\u1ea1o s\u1eed d\u1ee5ng hemerythrin, m\u1ed9t lo\u1ea1i protein c\u00f3 trong c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt kh\u00f4ng x\u01b0\u01a1ng s\u1ed1ng nh\u01b0 giun bi\u1ec3n. Hemerythrin \u1ed5n \u0111\u1ecbnh h\u01a1n hemoglobin v\u00e0 \u00edt b\u1ecb ph\u00e2n h\u1ee7y h\u01a1n khi kh\u00f4ng c\u00f3 c\u00e1c t\u1ebf b\u00e0o m\u00e1u. S\u1ea3n ph\u1ea9m c\u1ee7a Silaghi-Dumitrescu l\u00e0 s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a hemerythrin, mu\u1ed1i v\u00e0 albumin m\u00e0 \u00f4ng tin r\u1eb1ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c tinh ch\u1ebf th\u00e0nh m\u1ed9t dung d\u1ecbch “m\u00e1u t\u1ee9c th\u1eddi”.<\/p>\n\n

Nh\u1eefng c\u00e2n nh\u1eafc v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng<\/h2>\n\n

C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 c\u00e1c s\u1ea3n ph\u1ea9m m\u00e1u nh\u00e2n t\u1ea1o \u0111\u1eb7t ra nh\u1eefng lo ng\u1ea1i quan tr\u1ecdng v\u1ec1 m\u1eb7t \u0111\u1ea1o \u0111\u1ee9c. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u1ea3i c\u00e2n b\u1eb1ng gi\u1eefa c\u00e1c l\u1ee3i \u00edch ti\u1ec1m n\u0103ng c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 r\u1ee7i ro \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi tham gia. C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m (FDA) \u0111\u00e3 thi\u1ebft l\u1eadp c\u00e1c h\u01b0\u1edbng d\u1eabn nghi\u00eam ng\u1eb7t cho c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, bao g\u1ed3m s\u1ef1 \u0111\u1ed3ng \u00fd t\u1ef1 nguy\u1ec7n c\u1ee7a nh\u1eefng ng\u01b0\u1eddi tham gia v\u00e0 theo d\u00f5i ch\u1eb7t ch\u1ebd v\u1ec1 m\u1eb7t an to\u00e0n.<\/p>\n\n

So s\u00e1nh ch\u1ea5t thay th\u1ebf m\u00e1u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hemoglobin v\u00e0 hemerythrin<\/h2>\n\n

C\u00e1c ch\u1ea5t thay th\u1ebf m\u00e1u c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hemoglobin \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u r\u1ed9ng r\u00e3i h\u01a1n, nh\u01b0ng ch\u00fang ph\u1ea3i \u0111\u1ed1i m\u1eb7t v\u1edbi nh\u1eefng th\u00e1ch th\u1ee9c v\u1ec1 m\u1eb7t an to\u00e0n. C\u00e1c ch\u1ea5t thay th\u1ebf c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb hemerythrin, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ea3n ph\u1ea9m c\u1ee7a Silaghi-Dumitrescu, c\u00f3 nh\u1eefng l\u1ee3i th\u1ebf ti\u1ec1m n\u0103ng v\u1ec1 \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n. C\u1ea7n ph\u1ea3i nghi\u00ean c\u1ee9u th\u00eam \u0111\u1ec3 so s\u00e1nh hi\u1ec7u qu\u1ea3 v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn kh\u00e1c nhau n\u00e0y.<\/p>\n\n

Con \u0111\u01b0\u1eddng ph\u00e1p l\u00fd \u0111\u1ec3 ph\u00ea duy\u1ec7t c\u00e1c s\u1ea3n ph\u1ea9m m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

FDA \u0111\u00f3ng vai tr\u00f2 r\u1ea5t quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ph\u00ea duy\u1ec7t c\u00e1c s\u1ea3n ph\u1ea9m m\u00e1u nh\u00e2n t\u1ea1o. C\u01a1 quan n\u00e0y \u0111\u00e1nh gi\u00e1 \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a nh\u1eefng s\u1ea3n ph\u1ea9m n\u00e0y th\u00f4ng qua m\u1ed9t quy tr\u00ecnh xem x\u00e9t nghi\u00eam ng\u1eb7t. C\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t ph\u1ea3i cung c\u1ea5p d\u1eef li\u1ec7u \u0111\u1ea7y \u0111\u1ee7 t\u1eeb c\u00e1c nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt v\u00e0 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u01b0\u1edbc khi FDA c\u00f3 th\u1ec3 ph\u00ea duy\u1ec7t.<\/p>\n\n

L\u1ecbch s\u1eed th\u1ea5t b\u1ea1i c\u1ee7a c\u00e1c th\u00ed nghi\u1ec7m m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

Cu\u1ed9c t\u00ecm ki\u1ebfm m\u00e1u nh\u00e2n t\u1ea1o \u0111\u00e3 c\u00f3 c\u1ea3 th\u00e0nh c\u00f4ng v\u00e0 th\u1ea5t b\u1ea1i. M\u1eb7c d\u00f9 c\u00f3 nh\u1eefng l\u1eddi h\u1ee9a ban \u0111\u1ea7u, m\u1ed9t s\u1ed1 th\u00ed nghi\u1ec7m \u0111\u00e3 d\u1eabn \u0111\u1ebfn c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ho\u1eb7c th\u1eadm ch\u00ed t\u1eed vong. Nh\u1eefng th\u1ea5t b\u1ea1i n\u00e0y \u0111\u00e3 n\u00eau b\u1eadt nh\u1eefng th\u00e1ch th\u1ee9c trong vi\u1ec7c m\u00f4 ph\u1ecfng c\u00e1c t\u00ednh ch\u1ea5t ph\u1ee9c t\u1ea1p c\u1ee7a m\u00e1u t\u1ef1 nhi\u00ean.<\/p>\n\n

Vai tr\u00f2 c\u1ee7a Romania trong nghi\u00ean c\u1ee9u m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

M\u1eb7c d\u00f9 Romania c\u00f3 th\u1ec3 g\u1eafn li\u1ec1n v\u1edbi truy\u1ec1n thuy\u1ebft v\u1ec1 Dracula, qu\u1ed1c gia n\u00e0y c\u0169ng l\u00e0 n\u01a1i di\u1ec5n ra c\u00e1c nghi\u00ean c\u1ee9u ti\u00ean phong v\u1ec1 m\u00e1u nh\u00e2n t\u1ea1o. Nghi\u00ean c\u1ee9u c\u1ee7a Silaghi-Dumitrescu t\u1ea1i \u0110\u1ea1i h\u1ecdc Babe\u0219-Bolyai \u1edf Cluj-Napoca \u0111\u1ea1i di\u1ec7n cho m\u1ed9t \u0111\u00f3ng g\u00f3p quan tr\u1ecdng cho l\u0129nh v\u1ef1c n\u00e0y.<\/p>\n\n

Tri\u1ec3n v\u1ecdng t\u01b0\u01a1ng lai cho s\u1ef1 ph\u00e1t tri\u1ec3n m\u00e1u nh\u00e2n t\u1ea1o<\/h2>\n\n

S\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u00e1u nh\u00e2n t\u1ea1o v\u1eabn l\u00e0 m\u1ed9t l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c quan t\u00e2m. C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang kh\u00e1m ph\u00e1 nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn m\u1edbi, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ec3 nu\u00f4i c\u1ea5y c\u00e1c t\u1ebf b\u00e0o h\u1ed3ng c\u1ea7u ho\u1eb7c ch\u1ebf t\u1ea1o c\u00e1c ch\u1ea5t v\u1eadn chuy\u1ec3n oxy t\u1ed5ng h\u1ee3p. M\u1eb7c d\u00f9 v\u1eabn c\u00f2n nh\u1eefng th\u00e1ch th\u1ee9c, nh\u1eefng l\u1ee3i \u00edch ti\u1ec1m n\u0103ng c\u1ee7a m\u00e1u nh\u00e2n t\u1ea1o khi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t l\u0129nh v\u1ef1c \u0111\u1ea7y h\u1ee9a h\u1eb9n trong c\u00f4ng ngh\u1ec7 y t\u1ebf.<\/p>","protected":false},"excerpt":{"rendered":"

M\u00e1u nh\u00e2n t\u1ea1o: B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 y h\u1ecdc trong t\u01b0\u01a1ng lai Ph\u00e1t tri\u1ec3n m\u00e1u nh\u00e2n t\u1ea1o Trong nhi\u1ec1u th\u1ebf k\u1ef7, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm c\u00e1ch t\u1ea1o ra m\u1ed9t…<\/p>\n","protected":false},"author":2,"featured_media":24259,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1763],"tags":[5463,358,5465,5464],"class_list":["post-2744","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-artificial-blood","tag-medical-innovation","tag-healthtech","tag-hemerythrin"],"_links":{"self":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/comments?post=2744"}],"version-history":[{"count":2,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2744\/revisions"}],"predecessor-version":[{"id":24260,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/posts\/2744\/revisions\/24260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media\/24259"}],"wp:attachment":[{"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/media?parent=2744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/categories?post=2744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifescienceart.com\/vi\/wp-json\/wp\/v2\/tags?post=2744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}